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Dr. Bob is Robert Hsiung, MD,
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Posted by michael on March 9, 2001, at 0:11:52
Do these two (amisulpride & risperdal) work in the same fashion? The same mechanism/receptors/neurotransmiters/etc.?
If amisulpride made me feel worse, does that indicate a strong liklihood that I would get the same results with risperdal? Or are they different enough that one is not a good indicator for the other?
I know there is no way to know w/o trying, I'm just trying to get a feel where I should rank this on my list of options/next things to try. Also, what kind of dosage?
(btw - I'm looking at this as an option for augmenting wellbutrin, trying to address sluggishness, lack of energy/motivation, concentration, etc. - both mental & physical ). Thanks for any thoughts. michael
Posted by AndrewB on March 10, 2001, at 1:45:39
In reply to amisulpride and risperdal, posted by michael on March 9, 2001, at 0:11:52
Risperdal is significantly different from amisulpride. Amisulpride is a potent D2/D3 receptor antagonist.
Risperdal is a relatively weak D2 receptor antagonist. It is a potent 5-HT2A and 5HT7 antagonist. Also has a strong affinity for alpha 1 & 2 andrenergic and histimine H1 receptors. Not noted for weight gain like Zyprexa.
Low dosage range is 4 to 10 mg./day. 6mg. generally being more effective than the higher doses. Doses of 6 mg.s and lower a day greatly decrease the likelihood of EPS.
AndrewB
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