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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by PaulB on June 6, 2001, at 12:17:00
Hello, I am trying to find out more about the differences in the 5-HT2 antagonist properties of the similar antidepressants Nefazadone and Trazadone as I think it may be of relevance in regards to these drugs metabolite mCPP, 5-HT agonist
Nefazadone and Trazadone are both augmentors as well as antidepressants and when augmented with the popular SSRI's Paroxetine and Fluoxetine the levels of the metabolite mCPP can increase to a therapeutic level because the metabolising enzyme P450 CYP2D6 is potently inhibited by both these drugs. mCPP at higher levels would cause antidepressant/anxiolytic effects and 5-HT side-effects too.
What I wanted to find out is whether it is true that Nefazadone is a full antagonist at the 5-HT2 receptors and Trazadone blocks only 5-HT2a. If this were true Nefazadone may well block mCPP which is agonist at 5-HT2c and Trazadone wouldnt block mCPP from acting as an agonist at this particular receptor subtype.
Posted by SalArmy4me on June 6, 2001, at 12:31:22
In reply to Trazadone, Nefazadone and mCPP, posted by PaulB on June 6, 2001, at 12:17:00
Posted by PaulB on June 6, 2001, at 18:22:53
In reply to Re: Trazadone, Nefazadone and mCPP, posted by SalArmy4me on June 6, 2001, at 12:31:22
> http://www.preskorn.com/columns.html
Thanks for the link to this good website. So I was wrong then. Nefazadone is a potent antagonist of 5-HT2a only.
Posted by Jane D on June 6, 2001, at 23:32:30
In reply to Re: Trazadone, Nefazadone and mCPP, posted by SalArmy4me on June 6, 2001, at 12:31:22
> http://www.preskorn.com/columns.html
Sal,
Its a very nice site. Thanks for pointing it out.
Jane
Posted by Elizabeth on June 7, 2001, at 1:50:33
In reply to Trazadone, Nefazadone and mCPP, posted by PaulB on June 6, 2001, at 12:17:00
> Hello, I am trying to find out more about the differences in the 5-HT2 antagonist properties of the similar antidepressants Nefazadone and Trazadone as I think it may be of relevance in regards to these drugs metabolite mCPP, 5-HT agonist
To be clear about mCPP: it's extremely anxiogenic. It's often used to provoke panic attacks in laboratory settings. It's not what you want for an antidepressant.
-elizabeth
Posted by Lorraine on June 11, 2001, at 21:54:06
In reply to Thanks for the link » SalArmy4me, posted by Jane D on June 6, 2001, at 23:32:30
> > http://www.preskorn.com/columns.html
>
> Sal,
>
> Its a very nice site. Thanks for pointing it out.
>
> Jane
This is the end of the thread.
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