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Dr. Bob is Robert Hsiung, MD,
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Posted by SalArmy4me on June 9, 2001, at 22:09:39
In article < 92bpev$hfb$1@bugstomper.ihug.com.au >,
"Tom H." < Tom77@ihug.com.au.spam > writes:
Hi, whats the maximum dosage people typically go to on aurorix (moclobemide)? 600? 900?
I went up to 900, and have heard from others who've taken similar doses. I *think* that doses of up to 1200 are recommended in some cases, but I'd strongly recommend talking about this with your consultant before trying it.
Chris: I was told to treat it as a regular MAOI at doses of 900 and above, although I had no problems personally.Jack: Hey Tom,
I've been on this before, and my experience was that I had a little bit of activation, slight digestion disruption, and minor headache. All responded to symptomatic treatment, and passed within a few weeks. The only persistent complaint I had was insomnia, but that's actually not a likely side-effect, based on the literature. I required medication to encourage sleep.
This med was the only one that restored my full cognitive function. I gradually (over six months) regained normal emotional range. I lost twenty pounds without even trying, and I had no sexual side-effects of any sort. (If anything, my libido was a little high, not that that's a bad thing.) Over-all, the best med I ever tried, but unfortunately it "pooped-out" on me after about 16 months.
There are two categories of response to moclobemide; fast and slow responders. This difference is due to genetic variation in one key enzyme system. Fast responders feel better after only a couple weeks or so. Slow responders take more than eight weeks. I was a slow responder.
I'm not sure if it's listed there (moclobemide wasn't two years ago), but www.rxlist.com has usually got pretty comprehensive reports detailing adverse effects and interactions and the like.
Jane: Hi Tom !
I was on moclobemide (Aurorix) for ab. a year. Before that I tried many SSRIs (fluvoxamin Fevarin, fluoxetin Seronil, citalopram Cipramil, sertralin Zoloft) and also NARI (reboxetin Edronax). From all them exept moclobemide I got side effects mainly headache and anorgasmia. Moclobemide worked well on me and did it also with low doses. I started with 150mg a day for two weeks and then 300mg a day for a month. All depression faded away and I got back my energy. After that I reduced the dose down to 75mg a day which I continued almos a year. I had no side effects (perhaps only very slightly heartburn).
Hasa:Moclobemide worked really well for me the first time I tried it -- but then stopped after a couple of weeks for some reason. My girlfriend reckons that it might've been working because of a possble interaction with what I was taking previously (mirtazapine, aka Zispin/Remeron)
I didn't have a huge amount of success after that, even at 900mg doses, but don't take that as a necessarily bad thing: I seem to be fairly unresponsive to most ADs.
I've certainly heard more good than bad about moclobemide, and the professor guy who assessed me ages ago swears by it at high doses, reckoning that the reason it's not used more is that the usual dose range that's recommended, 150 - 600mg/day, is really too low to have enough of an effect.
So, in summary, I'm about the worst person to ask about the effectiveness of a med, but I have heard pretty good things about it.
Posted by Lorraine on June 10, 2001, at 0:01:59
In reply to Compendium of moclobemide responses, posted by SalArmy4me on June 9, 2001, at 22:09:39
I took a low dose of Mocloebemide (75-100mg) for about 2 months. It was immediately energizing, restored my mood, and cognitive functioning. Sex was good. Then I became over-activated on it and started hyperventilating. Reduced dose, but then no mood support. Gave up, finally. Also, slept ok but woke up not feeling refreshed. All in all a good drug if it works for you.
This is the end of the thread.
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