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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by JPR on June 9, 2001, at 21:39:29
Which of these is more effective for social anxiety/phobia with panic attacks, and personality avoidance disorder? What kind of side effects do each medications have ? Anyone with any information or experience please feel to respond.
Posted by SalArmy4me on June 9, 2001, at 21:53:54
In reply to PARNATE and NARDIL questions and experiences, posted by JPR on June 9, 2001, at 21:39:29
I don't know which one is better for which symptoms, but I post this from time to time because people tend to spread rumors that MAOI's are dangerous and outdated:
--I took Tranylcypromine for three months last year.
Dangerous?
Yes, there is a chance of a hypertensive crisis in which blood pressure increases so rapidly that a huge headache occurs. The chance of a hypertensive crisis from eating foods with tyramine is 6% from the last study done on it; modified to only 3% with the application of a special diet. These are pretty low percentages. But even if such a hypertensive crisis occurs, a simple dose of oral nifedipine will stop it immediately... The truth is that most hypertensive crises are mild, if they even occur.
Actually, there is more of a chance of _low_ blood pressure (orthostatic) with MAOIs than with the opposite. This may sound like a terrible illness, but it is merely annoying and does not cause any damage to the body. It may make you dizzy when you go from lying down to standing upright. It is easily remedied with a high sodium diet.
http://www.dr-bob.org/tips/split/Orthostatic-hypotension-on.html
If a first or second-line antidepressant fails for you, you should consider an MAOI (Phenelzine, Tranylcypromine, or the now available isocarboxazid. MAOIs are the only medications that work on three chemicals in the brain at once: maximizing chances of relief.)A disadvantage of MAOIs is that they can have severe interactions with other medications. Sometimes a Serotonin Syndrome or Neuroleptic Malignant Syndrome occurs. But to avoid such reactions, all you have to do is remember to ask your doctor before taking any medication with an MAOI. Or, you can use Dr. Koop's Drug Checker at www.drkoop.com.
MAOIs are perfectly safe, that is why they are still used after 40 years of existence. They just require that you get used to the idea of taking them and not erroneously think that they will kill you. Point in case: Nobody ever sees an article about someone dying from an MAOI in the paper.
Other stuff: http://www.dr-bob.org/tips/split/Orthostatic-hypotension-on.html
http://www.dr-bob.org/tips/split/MAOI-diet-update.html
Posted by shelliR on June 9, 2001, at 22:18:17
In reply to PARNATE and NARDIL questions and experiences, posted by JPR on June 9, 2001, at 21:39:29
> Which of these is more effective for social anxiety/phobia with panic attacks, and personality avoidance disorder? What kind of side effects do each medications have ? Anyone with any information or experience please feel to respond.
I don't have social anxiety/phobia but I do have depression and high anxiety. Nardil helped me for a very long time. I've heard that Parnate is less smooth and more energizing, so given the choice I'd probably choose go for Nardil. Until it lost it's effectiveness for me this past year, I can't say enough good things about it.
Shelli
Posted by Elizabeth on June 10, 2001, at 10:11:08
In reply to PARNATE and NARDIL questions and experiences, posted by JPR on June 9, 2001, at 21:39:29
> Which of these is more effective for social anxiety/phobia with panic attacks, and personality avoidance disorder?
Nardil is the better anxiolytic. I believe it inhibits GABA transaminase as well as monoamine oxidase.
(BTW, "avoidant personality disorder" is indistinguishable from generalised social phobia or social anxiety disorder.)
> What kind of side effects do each medications have?
The common side effects of irreversible nonselective MAOIs:
Parnate: activation; more insomnia; greater risk of hypertensive reactions to foods (this is usually not a problem if you know which foods to avoid)
Nardil: weight gain/increased appetite; sexual dysfunction
both: orthostatic hypotension; insomnia and possible daytime drowsiness (especially in the afternoon)
They are effective for social anxiety and panic disorder, Nardil in particular.
-elizabeth
Posted by matze on June 10, 2001, at 10:50:36
In reply to Re: Parnate and Nardil » JPR, posted by Elizabeth on June 10, 2001, at 10:11:08
> > Which of these is more effective for social anxiety/phobia with panic attacks, and personality avoidance disorder?
>
> Nardil is the better anxiolytic. I believe it inhibits GABA transaminase as well as monoamine oxidase.
>
> (BTW, "avoidant personality disorder" is indistinguishable from generalised social phobia or social anxiety disorder.)
>
> > What kind of side effects do each medications have?
>
> The common side effects of irreversible nonselective MAOIs:
>
> Parnate: activation; more insomnia; greater risk of hypertensive reactions to foods (this is usually not a problem if you know which foods to avoid)
>
> Nardil: weight gain/increased appetite; sexual dysfunction
>
> both: orthostatic hypotension; insomnia and possible daytime drowsiness (especially in the afternoon)
>
> They are effective for social anxiety and panic disorder, Nardil in particular.
>
> -elizabeth
Hi,
Does phenelzine cause more sexual side effects than parnate? I am male and consider parnate for
dysthymia/major depression.
Posted by shelliR on June 10, 2001, at 11:13:17
In reply to Re: Parnate and Nardil, posted by matze on June 10, 2001, at 10:50:36
>
> >
> > Nardil: weight gain/increased appetite; sexual dysfunctionJust as far as myself (N=1), I had no weight gain and no sexual dysfunction on Nardil.
> >
> > both: orthostatic hypotension; insomnia and possible daytime drowsiness (especially in the afternoon)I did have insomnia at higher doses and daytime drowsiness (especially in the afternoon).
But I have never gone above 45mg of nardil because of the insomnia, so maybe that's why no weight gain or sexual dysfunction.
shelli
> >
> >
>
Posted by SalArmy4me on June 10, 2001, at 17:32:14
In reply to PARNATE and NARDIL questions and experiences, posted by JPR on June 9, 2001, at 21:39:29
I got a s@#!%y deal!!!!!
Posted by Elizabeth on June 10, 2001, at 20:38:57
In reply to Re: Parnate and Nardil, posted by matze on June 10, 2001, at 10:50:36
> Does phenelzine cause more sexual side effects than parnate? I am male and consider parnate for
> dysthymia/major depression.I think Nardil is the worse one in that department. I didn't get the side effect on either of them, but it seems to me that more people have problems with phenelzine.
-elizabeth
Posted by JohnM on June 11, 2001, at 17:32:32
In reply to PARNATE and NARDIL questions and experiences, posted by JPR on June 9, 2001, at 21:39:29
I've read that Nardil is more effective with Social Phobia than Parnate. I have used Nardil before and it worked.
This is the end of the thread.
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