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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by John Rey on October 12, 2001, at 21:26:02
First I like to say that I suffer from Social Anxiety Disorder (or social phobia), so much so that I also have what is called Avoidant Personality Disorder. I have also Panic Disorder, too. I have tried almost every AD med with little or no success. The only two meds that help me were the benzos Klonopin and Xanax, especially the Xanax. The klonopin works but only about half of the time. And I do not like the effect it has my memory or cognitive ability. One of the questions I have is would Parnate or Nardil be more effective for the conditions I have? Also do they affect the major neurotransmitters the same or differently? Does it depend on dosage of Parnate or Nardil? Which one would be more faster acting? Lastly, which of these two meds (Parnate or Nardil) would affect my memory or cognitive skills more, if at all? Please anyone with information or experiences on Nardil or Parnate feel free to respond.
Posted by Elizabeth on October 13, 2001, at 17:52:18
In reply to Parnate and Nardil questions, posted by John Rey on October 12, 2001, at 21:26:02
> First I like to say that I suffer from Social Anxiety Disorder (or social phobia), so much so that I also have what is called Avoidant Personality Disorder.
FWIW, there's no real difference between generalized social phobia and "avoidant personality disorder." Diagnostically, they're indistinguishable.
> I have also Panic Disorder, too.
So what you're saying is that you're a very anxious person?!
> I have tried almost every AD med with little or no success. The only two meds that help me were the benzos Klonopin and Xanax, especially the Xanax. The klonopin works but only about half of the time.
Were you taking them regularly (like, 2-4 times a day) or "as needed?" Benzodiazepines are probably the best-tolerated medications for social phobia and panic disorder.
> One of the questions I have is would Parnate or Nardil be more effective for the conditions I have?
Yes, MAOIs are very effective for both social phobia and panic disorder.
> Also do they affect the major neurotransmitters the same or differently?
About the same. One major difference is that Nardil increases the concentration of GABA in the brain.
> Does it depend on dosage of Parnate or Nardil?
I think Nardil is better for anxiety, while Parnate may have stimulant-like effects. (Parnate is still effective for anxiety disorders, though, so don't rule it out.)
> Which one would be more faster acting?
Hard to predict, but MAOIs often seem to start working faster than other antidepressants.
> Lastly, which of these two meds (Parnate or Nardil) would affect my memory or cognitive skills more, if at all?
Can't predict. I didn't have such problems with either one, though.
Hope this helps. Good luck!
-elizabeth
Posted by dennison on October 14, 2001, at 5:43:32
In reply to Parnate and Nardil questions, posted by John Rey on October 12, 2001, at 21:26:02
> First I like to say that I suffer from Social Anxiety Disorder (or social phobia), so much so that I also have what is called Avoidant Personality Disorder. I have also Panic Disorder, too. I have tried almost every AD med with little or no success. The only two meds that help me were the benzos Klonopin and Xanax, especially the Xanax. The klonopin works but only about half of the time. And I do not like the effect it has my memory or cognitive ability. One of the questions I have is would Parnate or Nardil be more effective for the conditions I have? Also do they affect the major neurotransmitters the same or differently? Does it depend on dosage of Parnate or Nardil? Which one would be more faster acting? Lastly, which of these two meds (Parnate or Nardil) would affect my memory or cognitive skills more, if at all? Please anyone with information or experiences on Nardil or Parnate feel free to respond.
Hi I've taken parnate for quite a few years,one of it's biggest advantages was that it had absolutely no blunting effect on cognition in fact it enhanced. Every other anti-depressant i've taken over the years and there have been many all interferred with abilty to think especially short term working memory deficit. Maoi's effect serotonin norepinephrine dopamine and phenylethylamines "pea" so their spectrum is a good deal different then classical reuptake inhibitors or the atypical anti-depressants. Parnate usually works quicker than other anti-depressants partially because the molecule itself has some sympathomimetic effects but whatever the reason it tends to work fairly quickly usually in days!! Biggest drawback is possible "hypo"tension, yes I said hypotension as maoi's tend to lower blood pressure. The food and drug restrictions are actually extremely minimal to prevent a possible "hyper" tensive crisis mainly aged cheeses, redwine and otc drug's with an indirectly acting sympathomimetic effect- ex. pseudoephedrine. Dextromethrophan also should be avoided!! Good Luck :):)
Posted by Elizabeth on October 14, 2001, at 10:40:20
In reply to Re: Parnate and Nardil questions, posted by dennison on October 14, 2001, at 5:43:32
> The food and drug restrictions are actually extremely minimal to prevent a possible "hyper" tensive crisis mainly aged cheeses, redwine and otc drug's with an indirectly acting sympathomimetic effect- ex. pseudoephedrine. Dextromethrophan also should be avoided!! Good Luck :):)
Red wine is okay, actually. A lot of the supposed restrictions turned out to be superfluous.
Let us know how it goes for you!
-elizabeth
Posted by kregpark@yahoo.com on October 20, 2001, at 15:48:53
In reply to Re: Parnate and Nardil questions, posted by dennison on October 14, 2001, at 5:43:32
I really agree with the comments on Parnate.
For those who do not get too anxious on it it can be extremely effective.
Some doctors say there most dramatic (and best) responses have been to Parnate.
That it.. the ones who know the facts about it!!Unfortunately many docs do not understand it is very safe provided that other ssri's and serotonin based meds are combined simeoultaneously (serotonin syndrome).
kregpark
http://www.socialfear.com/
> > First I like to say that I suffer from Social Anxiety Disorder (or social phobia), so much so that I also have what is called Avoidant Personality Disorder. I have also Panic Disorder, too. I have tried almost every AD med with little or no success. The only two meds that help me were the benzos Klonopin and Xanax, especially the Xanax. The klonopin works but only about half of the time. And I do not like the effect it has my memory or cognitive ability. One of the questions I have is would Parnate or Nardil be more effective for the conditions I have? Also do they affect the major neurotransmitters the same or differently? Does it depend on dosage of Parnate or Nardil? Which one would be more faster acting? Lastly, which of these two meds (Parnate or Nardil) would affect my memory or cognitive skills more, if at all? Please anyone with information or experiences on Nardil or Parnate feel free to respond.
> Hi I've taken parnate for quite a few years,one of it's biggest advantages was that it had absolutely no blunting effect on cognition in fact it enhanced. Every other anti-depressant i've taken over the years and there have been many all interferred with abilty to think especially short term working memory deficit. Maoi's effect serotonin norepinephrine dopamine and phenylethylamines "pea" so their spectrum is a good deal different then classical reuptake inhibitors or the atypical anti-depressants. Parnate usually works quicker than other anti-depressants partially because the molecule itself has some sympathomimetic effects but whatever the reason it tends to work fairly quickly usually in days!! Biggest drawback is possible "hypo"tension, yes I said hypotension as maoi's tend to lower blood pressure. The food and drug restrictions are actually extremely minimal to prevent a possible "hyper" tensive crisis mainly aged cheeses, redwine and otc drug's with an indirectly acting sympathomimetic effect- ex. pseudoephedrine. Dextromethrophan also should be avoided!! Good Luck :):)
This is the end of the thread.
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