Psycho-Babble Medication Thread 81737

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Re: Mianserin » ADgirl

Posted by JohnX on October 21, 2001, at 16:54:44

In reply to Mianserin, posted by ADgirl on October 20, 2001, at 0:34:11

ADGirl,

Mianserin does not have the alpha-2 adrenergic
blocking action that Mirtazapine has which
statistically made it less of an anti-depressant.
It does have the same anti-histamine side
effect that helps with your sleep. Also from what
I remember it is a more selective antagonist at the serotonin 5ht-2a and 2c receptors, which would
also help with anxiety and sexual dysfunction and
the other things you mentioned.

Good luck on your med, I'm glad it
works for you. Its more popular in Europe
from what I understand, but primarily to
augment other meds.

BTW, I found an interesting paper from Organon
they have found dirivatives of
mianserin/mirtazepine that don't have the
anti-histamine binding side effect. I assume
they are studying these medications to get
them into the pipeline, but they are probably
behind other companies trying to achieve the
same thing (clean 5ht-2a/c antagonism with other
anti-depressant actions).

-John

> Oddly enough, I have found mianserin to work better than mirtazapine. My 90 mg dose of mianserin has worked better than even the highest mirtazapine dose of 90 mg. So I believe there is a difference between the two. I have heard of people complaining about more sedation with mianserin, but this to me is a desirable effect on insomnia. I have had no other side-effects from it.
>
> In the literature, Mianserin is noted as having an anti-migraine effect, as well as a beneficial effect on neuroleptic-induced akasthisia. Also, it is sometimes used like mirtazapine for SSRI-induced sexual dysfunction.
>
> Mianserin is not available in the United States, but I got ahold of it anyway through an online company. It costs less than mirtazapine because it is available as a generic.

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