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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by BrittPark on September 19, 2002, at 12:17:12
Hi,
I've decided that it would be an interesting project and perhaps useful to people on the board to put together a comprehensive table of biochemical psychopharmaceutical data, binding constants to different receptors, localization of effects etc.
So, if you have already dug up biochemical data about any psychopharmaceutical I'd be greatly obliged if you'd forward it to me to add to the compendium.
Britt
Posted by Phil on September 19, 2002, at 13:07:57
In reply to Biochemical data on psychopharmaceuticals., posted by BrittPark on September 19, 2002, at 12:17:12
BrittPark, Will this help simplify which drugs hit which receptors?
Can you give me an outline of the kinds of things you'll want?
It would be great, especially if you are on several drugs and could get a better grasp of what really is happening. Thanks.Sleeping in science class,
Phil
Posted by BrittPark on September 19, 2002, at 13:29:18
In reply to Re: Biochemical data on psychopharmaceuticals. » BrittPark, posted by Phil on September 19, 2002, at 13:07:57
> BrittPark, Will this help simplify which drugs hit which receptors?
That's the intention. With reliable biochemical data it might be easier for people on the board to figure out what may work based on past experience.
> Can you give me an outline of the kinds of things you'll want?
Accurate receptor binding constants mostly, but also data on receptor up and down regulation, and any other mechanistic information known.
> It would be great, especially if you are on several drugs and could get a better grasp of what really is happening. Thanks.
>
> Sleeping in science class,
>
> PhilThanks for the encouragement.
Britt
Posted by Eddie Sylvano on September 19, 2002, at 14:18:03
In reply to Biochemical data on psychopharmaceuticals., posted by BrittPark on September 19, 2002, at 12:17:12
> I've decided that it would be an interesting project and perhaps useful to people on the board to put together a comprehensive table of biochemical psychopharmaceutical data, binding constants to different receptors, localization of effects etc.
----------------------
I had posted an idea relatively similar to this a while ago:
http://www.dr-bob.org/babble/20020814/msgs/117084.html
with the more general idea of attempting to define pharmacological profiles. I could see your concept being a natural adjunct to this, as both a reference, and potential refinement to the profiles (when individual variables are known). I've also become interested in the dynamics of the cytochrome P450 interactions in drug "interactions," with the idea of a tool that would allow someone to enter their regimen into a form which would advise on any positive/negative interactions. Nutritional habits can also widely affect drug half-lives, such as the enhancing effect grapefruit juice has on certain benzodiazepines (Xanax, Halcion).
There are currently a few tools, such as the P450 datbase at http://gentest.com/human_p450_database/
Given that I already have the requisite server and bandwidth, I've been considering developing a site like that as a Master's thesis.
Any thoughts?
Posted by IsoM on September 19, 2002, at 15:07:35
In reply to Biochemical data on psychopharmaceuticals., posted by BrittPark on September 19, 2002, at 12:17:12
Another poster, SLS, has already made a very good, but still basic (for your needs) table of psychotropic drugs that may interest you.
http://sl.schofield3.home.att.net/medicine/psychiatric_drugs_chart.html
If you want to contract him further about it, you can email him at sl.schofield@att.net
Posted by BrittPark on September 19, 2002, at 15:22:06
In reply to Re: Biochemical data on psychopharmaceuticals., posted by Eddie Sylvano on September 19, 2002, at 14:18:03
I think it would be a great Masters thesis. I'm a postdoc myself (in computational chemistry) so my efforts can be little more than amateur. Send me your E-mail and I'll be sure to send you whatever I find.
Posted by BrittPark on September 19, 2002, at 15:26:15
In reply to Re: Biochemical data on psychopharmaceuticals., posted by IsoM on September 19, 2002, at 15:07:35
Thanks for the pointer. It's an extremely useful resource.
Posted by Phil on September 19, 2002, at 17:41:41
In reply to Re: Biochemical data on psychopharmaceuticals. » IsoM, posted by BrittPark on September 19, 2002, at 15:26:15
Posted by Jonathan on September 19, 2002, at 23:43:13
In reply to Re: Biochemical data on psychopharmaceuticals., posted by Eddie Sylvano on September 19, 2002, at 14:18:03
http://www.gpcr.org/7tm/ligand/ligand.html
http://psychiatry.uchicago.edu/grounds/010402/slides/
This is the end of the thread.
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