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Dr. Bob is Robert Hsiung, MD,
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Posted by linkadge on March 30, 2003, at 19:02:15
I heard that bcl-2 is a 'good' neuroprotective
protein, and that lithium raises it.
does high 'expression' of the bcl-2 gene
mean high levels of this neuroprotective
protein. I'm just trying to interpret the
meaning of a gingko biloba study.
Thanks
Linkadge
Posted by Shawn. T. on March 30, 2003, at 20:16:20
In reply to bcl-2 expression - HELP, posted by linkadge on March 30, 2003, at 19:02:15
Yes. Here's a good definition:
"expression: The cellular production of the protein encoded by a particular gene. The process includes transcription of DNA, processing of the resulting mRNA product and its translation into an active protein. N.B. A recombinant gene inserted into a host cell by means of a vector is said to be expressed if the synthesis of the encoded polypeptide can be demonstrated." [IUPAC Bioinorganic, IUPAC Compendium]
-That should explain expression, transcription, and translation; you'll see those three terms used regularly. As a side note, I don't believe that increased bcl-2 activity is responsible for lithium's efficacy in bipolar disorder; its inhibitory effects on protein kinase C (PKC) alpha are probably much more important.
Shawn
Posted by Dragonslayer on March 30, 2003, at 20:42:40
In reply to Re: bcl-2 expression - HELP, posted by Shawn. T. on March 30, 2003, at 20:16:20
This is the end of the thread.
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