Psycho-Babble Medication Thread 235911

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Good Way To Lower Cortisol

Posted by davpet on June 21, 2003, at 17:16:37

Check out this link of the use of anti-glucocorticoids in depression . In the one study they used aminoglutethimide to suppress endogenous cortisol and then added just enough synthetic cortisol to keep cortisol within the low-normal range, thus creating a net reduction in cortisol levels (so as not to interrupt negative feedback inhibition , but to allow for glucocorticoid-receptor up-regulation due to lower hormone exposure)

http://www.utmj.org/issues/77.1/pdf/Psych77-1.pdf


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