Psycho-Babble Medication Thread 245266

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Protein Kinase C inhibitors

Posted by linkadge on July 25, 2003, at 16:34:01

I have been using my manic energies to search for different antimanic agents.

I has come to my attention that most of the effective mood stabilizers have protein kinase c inhibition abilities.

Here are some of the protein kinase c inhibitors that I have tried and there effects.

Vitamin E - Reportedly blunts excess protein kinase c espression. Definately has an antimanic effect at 2000IU. However it has a dopamine enhancing effect, that made me quite irritable.
But it did completely stop all mind racing.

Fish Oil - Works for mind racing and cycling of emotion. Keeps me in a constant state, but again the dopamine effect makes me irritable and angry.

Quercetin - Wonderful wonderful. I say with all honesty that if you are manic, then 500-1000mg od quercetin will definately calm the core of you down. It suposedly is one of the most potent PKC inhibitors (natural) available.

Selenium - Definately will take you out of a manic high, but it makes me depressed if I take more than 200 mcgs.

After the descovery that Tamoxafan was antimanic I have been interested in this area. I am convinced that PKC really is the final common target of mood stabalizers.

Linkadge

Very Interesting! What is Kinase C? (nm) » linkadge

Posted by River1924 on July 26, 2003, at 0:23:57

In reply to Protein Kinase C inhibitors, posted by linkadge on July 25, 2003, at 16:34:01

Re: Very Interesting! What is Kinase C?

Posted by linkadge on July 26, 2003, at 1:15:35

In reply to Very Interesting! What is Kinase C? (nm) » linkadge, posted by River1924 on July 26, 2003, at 0:23:57

Im not exactly a scientist, but protein kinase c is a family of kinases that are involved in cellular growth.

Protein kinase C is involved in the regulation of inositol content/distibutionin the brain

Basically high levels of protein kinase C are is one of the only biological markers specific to mania. The effective mood stabalizers all act at by inhibiting protein kinase c. After PKC is inhibited or lowered this leads to chain of events which lower inositol levels in certain areas of the brain.

Recent studies were done using the cancer drug tamoxephen (which happens to be a potent PKC inhibitor). It resulted in rapid reduction of manic symptoms within 7 of 10 of the manic patients involved. Specific PKC inhibitors are being developed but are yet unavailable.

I have been searching for any/all infomation relating different compounds' abilities to inhibit PKC. Some of the major ones I have found are:

Quercetin,
Green Tea,
Vitamin E
Curcumin,

I have expereienced rapid reduction in my manic symptoms following doses of quercetin 500mg, vitamin e produces some of the same effect however not as dramatic.

I describe the sensation as very rapid. It is as if I was a inflatable dummy and somebody pricked me with a pin. I start to deflate and all of a sudden my thoughts become remarkably more clear.

I am personally convinced that PKC pathways are at the core of manic symptoms. I am telling everybody on this board now that sooner or later a lot of people will be relieved when specific PKC inhibiors are released.

Best Of Luck

Linkadge

Re: Very Interesting! What is Kinase C? » linkadge

Posted by samplemethod on July 26, 2003, at 6:42:16

In reply to Re: Very Interesting! What is Kinase C?, posted by linkadge on July 26, 2003, at 1:15:35

Good work linkadge...

you now advance to the next level. Only joking :)

I have started to take vit e after your advice a couple of months ago.. dunno about how much it affected me but i wasnt really a manic type of guy. I just liked the way you mentioned it shrunk the world and basically I started it cos I didnt think I had enough in my diet anyway. Have recently reduce my dosage to 1000mg from 1500...

anyway I've seen quercetin on one of my vit supps somewhere I think... I dunno in which it is at the moment.

anyway I will try it out and see what it does

cheers mate and congratulations on your investigations

> Im not exactly a scientist, but protein kinase c is a family of kinases that are involved in cellular growth.
>
> Protein kinase C is involved in the regulation of inositol content/distibutionin the brain
>
> Basically high levels of protein kinase C are is one of the only biological markers specific to mania. The effective mood stabalizers all act at by inhibiting protein kinase c. After PKC is inhibited or lowered this leads to chain of events which lower inositol levels in certain areas of the brain.
>
> Recent studies were done using the cancer drug tamoxephen (which happens to be a potent PKC inhibitor). It resulted in rapid reduction of manic symptoms within 7 of 10 of the manic patients involved. Specific PKC inhibitors are being developed but are yet unavailable.
>
> I have been searching for any/all infomation relating different compounds' abilities to inhibit PKC. Some of the major ones I have found are:
>
> Quercetin,
> Green Tea,
> Vitamin E
> Curcumin,
>
> I have expereienced rapid reduction in my manic symptoms following doses of quercetin 500mg, vitamin e produces some of the same effect however not as dramatic.
>
> I describe the sensation as very rapid. It is as if I was a inflatable dummy and somebody pricked me with a pin. I start to deflate and all of a sudden my thoughts become remarkably more clear.
>
> I am personally convinced that PKC pathways are at the core of manic symptoms. I am telling everybody on this board now that sooner or later a lot of people will be relieved when specific PKC inhibiors are released.
>
>
> Best Of Luck
>
> Linkadge
>

A caution

Posted by linkadge on July 26, 2003, at 15:34:07

In reply to Re: Very Interesting! What is Kinase C? » linkadge, posted by samplemethod on July 26, 2003, at 6:42:16

About a year back when I took Quercetin (when I felt relitivly happy) It did seem to flatten my mood a little.

While some people consider the med a natural sedative and useful for anxiety disorders
just be aware that it may dampen the mood a little.

But heres some info on how PKC effects the anxiety system. Keep in mind Quercetin and Vitamin E are fairly potent PKC inhibitors

http://www.sciencedaily.com/releases/2002/10/021002065855.htm

Linkadge

Links to research involving PKC and mania

Posted by Shawn. T. on July 27, 2003, at 0:12:01

In reply to A caution, posted by linkadge on July 26, 2003, at 15:34:07

Try http://www.neurotransmitter.net/bipolarpkc.html

Also, note that the PKC isoform most likely to be involved in bipolar disorder is PKC alpha.

Shawn

although epsilon involved in anxiety (nm)

Posted by linkadge on July 27, 2003, at 16:59:05

In reply to Links to research involving PKC and mania, posted by Shawn. T. on July 27, 2003, at 0:12:01

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