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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by lostforwards on October 29, 2004, at 10:37:56
See, I hear all this stuff about sexual side-effects from antidepressants that work on serotonin. Isn't depression due to stress? Does stress effect serotonin in any way?? ... What do they have against dopamine-only reuptake inhibitors? or even NDRI's? Are they afraid we'll all become to sexual and/or hyper or something?
I had an ex on an antidepressant and her interest in sex was blah...she was very mellow.
mellow people are good for the country, they don't kick up a fuss.. they're quite, don't talk too much..hmmmmmm...Sounds like a conspiracy to me.don't mind me, just trying wondering.. are there any good places to find how personality is affected by brain chemistry?
Posted by linkadge on October 29, 2004, at 11:00:28
In reply to is depression more about dopamine or serotonin?, posted by lostforwards on October 29, 2004, at 10:37:56
I think there are different subtypes of depression that respond to different treatements.
Anergenic and anhedonic individuals probably have low dopamine. However pessemistic anxious insomniacs probably respond to the inhibitory actions of the SSRIs. Depression is supposedly related to lower levels of growth factors in the hippocampus. SSRI's enhance neurogenesis as do most effective antidepressants.
Statistically, ECT, the most effective antidepressant, has strong effects on serotonin neurotransmission as well as dopamine.
So is dopamine, more involved than serotonin ?, I think it depends on the person.
I was angry and irritable on ritalin, but calmer and happier on celexa. For some, it is the opposite.
Linkadge
Posted by sabre on October 29, 2004, at 23:49:25
In reply to Re: is depression more about dopamine or serotonin?, posted by linkadge on October 29, 2004, at 11:00:28
I wonder how a drug like Tianeptine works. It enhances the reuptake of serotonin, working in the opposite way to the ssris.
Makes me wonder if depression and anxiety may be more about regulation and balance rather than excess/deficiency of neurotransmitters.
This would explain why it can take weeks before you feel better. It may also explain why you can have drastically different dosages between patients and have a similar outcome. The dosage you take may just act to reset your balance.
What sits above the levels of serotonin, dopamine and NA in the chain of command. What is the fat controller(s)??
sabre
Posted by Sebastian on October 30, 2004, at 10:23:47
In reply to is depression more about dopamine or serotonin?, posted by lostforwards on October 29, 2004, at 10:37:56
Most of these meds are for stress. Thats what mental illness is all about.
Posted by linkadge on October 31, 2004, at 8:05:12
In reply to Re: is depression more about dopamine or serotonin?, posted by Sebastian on October 30, 2004, at 10:23:47
Depression *often* occurs in the absence of any detectable mental stressors.
I have read studies that show that tianeptine regulates the hpa axis as do other antidepressants. I have also read studies that show it downregulates the 5-ht2a receptors like other antidepressants. It also causes adaptive changes in the d2/d3 receptors like other antidepressants. The neurotransmitters are just the first stage, the final targets are probably cellular (BDNF, NGF, cortisol, CREB, PKC etc)
Linkadge
This is the end of the thread.
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