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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 18 of 18. This is the beginning of the thread.
Posted by ixus on May 30, 2005, at 10:24:12
Hi,
after initial success, I started to develop depression on Nardil. I was so positive about the drug at the beginning. No serious side effects. Breakdown came after 10 days. I felt I was loosing contact with the ground. I was so delicate.
Now caffeine keeps my depression at bay, and it must for at least 10 days... After your warnings, I won't start Parnate again immediately./ixus
Posted by Maxime on May 30, 2005, at 11:44:02
In reply to Nardil, the end of the story, posted by ixus on May 30, 2005, at 10:24:12
Hi Ixus, I am sorry to hear that. It's funny that it would work so well at first.
Did anything happen in your life that would cause the depression.
Maxime
> Hi,
> after initial success, I started to develop depression on Nardil. I was so positive about the drug at the beginning. No serious side effects. Breakdown came after 10 days. I felt I was loosing contact with the ground. I was so delicate.
> Now caffeine keeps my depression at bay, and it must for at least 10 days... After your warnings, I won't start Parnate again immediately.
>
> /ixus
>
Posted by ixus on May 30, 2005, at 12:37:40
In reply to Re: Nardil, the end of the story » ixus, posted by Maxime on May 30, 2005, at 11:44:02
> Hi Ixus, I am sorry to hear that. It's funny that it would work so well at first.
>
> Did anything happen in your life that would cause the depression.
>
> Maxime
>Absolutely nothing, and this is very sad.
/ixus
Posted by ed_uk on May 30, 2005, at 13:30:03
In reply to Re: Nardil, the end of the story » Maxime, posted by ixus on May 30, 2005, at 12:37:40
Hi Ixie,
I just emailed you.
Yours,
Ed.
Posted by willyee on May 30, 2005, at 14:49:09
In reply to Nardil, the end of the story, posted by ixus on May 30, 2005, at 10:24:12
> Hi,
> after initial success, I started to develop depression on Nardil. I was so positive about the drug at the beginning. No serious side effects. Breakdown came after 10 days. I felt I was loosing contact with the ground. I was so delicate.
> Now caffeine keeps my depression at bay, and it must for at least 10 days... After your warnings, I won't start Parnate again immediately.
>
> /ixus
>
When i switched from Nardil back to parnate after finaly stop being in denial i noticed parnates dopamine effects were most appehearnt.And after back on it,during fatigue i used caffiene pills to add a more dopamine type feel to parnate,i often had wondered what would have been the case if i tried to simply make Nardil more of a dopamine drug....perhaps the caffiene was giving u the edge the nardil needed,did the caffiene seem to interact with nardil,do you think you maybe adding caffiene permantly would have helped nardil work better and not loose what parnate offers,on papaer nardil should be the better choice,its non reversable for sure,it increases PEA and has a metobolite that does something with gaba,parnates strong effect on dopamine is the missing key,caffiene wasnt enough to pull that off with nardil you dont thinnk?
Posted by Maxime on May 30, 2005, at 15:08:36
In reply to Re: Nardil, the end of the story, posted by willyee on May 30, 2005, at 14:49:09
I saw an article that says you can a stimulant or provigil while on Nardil. That would help.
Maxime
> > Hi,
> > after initial success, I started to develop depression on Nardil. I was so positive about the drug at the beginning. No serious side effects. Breakdown came after 10 days. I felt I was loosing contact with the ground. I was so delicate.
> > Now caffeine keeps my depression at bay, and it must for at least 10 days... After your warnings, I won't start Parnate again immediately.
> >
> > /ixus
> >
>
>
> When i switched from Nardil back to parnate after finaly stop being in denial i noticed parnates dopamine effects were most appehearnt.
>
> And after back on it,during fatigue i used caffiene pills to add a more dopamine type feel to parnate,i often had wondered what would have been the case if i tried to simply make Nardil more of a dopamine drug....perhaps the caffiene was giving u the edge the nardil needed,did the caffiene seem to interact with nardil,do you think you maybe adding caffiene permantly would have helped nardil work better and not loose what parnate offers,on papaer nardil should be the better choice,its non reversable for sure,it increases PEA and has a metobolite that does something with gaba,parnates strong effect on dopamine is the missing key,caffiene wasnt enough to pull that off with nardil you dont thinnk?
>
Posted by Phillipa on May 30, 2005, at 16:53:12
In reply to Re: Nardil, the end of the story » willyee, posted by Maxime on May 30, 2005, at 15:08:36
Darn you guys are knowledgeable. Fondly, Phillipa
Posted by ixus on May 31, 2005, at 1:37:10
In reply to Re: Nardil, the end of the story, posted by willyee on May 30, 2005, at 14:49:09
> When i switched from Nardil back to parnate after finaly stop being in denial i noticed parnates dopamine effects were most appehearnt.
>
> And after back on it,during fatigue i used caffiene pills to add a more dopamine type feel to parnate,i often had wondered what would have been the case if i tried to simply make Nardil more of a dopamine drug....perhaps the caffiene was giving u the edge the nardil needed,did the caffiene seem to interact with nardil,do you think you maybe adding caffiene permantly would have helped nardil work better and not loose what parnate offers,on papaer nardil should be the better choice,its non reversable for sure,it increases PEA and has a metobolite that does something with gaba,parnates strong effect on dopamine is the missing key,caffiene wasnt enough to pull that off with nardil you dont thinnk?
>IMHO there are 2 major contributors to the failure:
-strong GABA effect (actually may be depressing)
-total lack of dopamine
-potential Parnate addictionThis would also explain why I responded only to Parnate and fluoxetine ( as I know fluoxetine has dopaminergic effect too).
/ixus
Posted by Maxime on May 31, 2005, at 9:52:17
In reply to Re: Nardil, the end of the story » willyee, posted by ixus on May 31, 2005, at 1:37:10
>
> > When i switched from Nardil back to parnate after finaly stop being in denial i noticed parnates dopamine effects were most appehearnt.
> >
> > And after back on it,during fatigue i used caffiene pills to add a more dopamine type feel to parnate,i often had wondered what would have been the case if i tried to simply make Nardil more of a dopamine drug....perhaps the caffiene was giving u the edge the nardil needed,did the caffiene seem to interact with nardil,do you think you maybe adding caffiene permantly would have helped nardil work better and not loose what parnate offers,on papaer nardil should be the better choice,its non reversable for sure,it increases PEA and has a metobolite that does something with gaba,parnates strong effect on dopamine is the missing key,caffiene wasnt enough to pull that off with nardil you dont thinnk?
> >
>
> IMHO there are 2 major contributors to the failure:
> -strong GABA effect (actually may be depressing)
> -total lack of dopamine
> -potential Parnate addiction
>
> This would also explain why I responded only to Parnate and fluoxetine ( as I know fluoxetine has dopaminergic effect too).
> /ixusHey I have only ever responded to Prozac and Parnate as well.
Maxime
>
>
Posted by ixus on May 31, 2005, at 11:43:29
In reply to Re: Nardil, the end of the story » ixus, posted by Maxime on May 31, 2005, at 9:52:17
> Hey I have only ever responded to Prozac and Parnate as well.
>
Welcome in the club!
Update: I started Parnate 10mg bid and I feel a huge relief.
/ixus
Posted by Phillipa on May 31, 2005, at 16:34:22
In reply to Re: Nardil, the end of the story » Maxime, posted by ixus on May 31, 2005, at 11:43:29
Wait a minute! Talk english to me. Because when prozac first came out only in 20mg capsules my pdoc asked me to try it. The first day I wallpapered the foyer, the second day I was anxious, and the third day I was in total panic. I stopped taking the med and it took 3 days of xanax to come back to my very, at the time, functional working self. The pdoc said when I next saw him "please keep taking it you had such a dramatic response to it. Only take it every three days". Well I refused. So would this mean that prozac would be a good drug for me maybe in smaller doses? Fondly, Phillipa
Posted by ed_uk on May 31, 2005, at 16:57:13
In reply to Re: Nardil, the end of the story » ixus, posted by Phillipa on May 31, 2005, at 16:34:22
Hi PJ!
>So would this mean that prozac would be a good drug for me maybe in smaller doses?
Were you thinking of replacing Zoloft with Prozac? Perhaps you could try 5mg Prozac per day.
Ed xxx
Posted by Phillipa on May 31, 2005, at 17:21:21
In reply to Re: Nardil, the end of the story » Phillipa, posted by ed_uk on May 31, 2005, at 16:57:13
Hi Ed! I don't know what to think. It was so long ago. And my chemistry's changed. What do you think? Fondly, Phillipa
Posted by ed_uk on May 31, 2005, at 17:31:40
In reply to Re: Nardil, the end of the story » ed_uk, posted by Phillipa on May 31, 2005, at 17:21:21
Hi PJ!
>What do you think?
It could be worth trying a very low dose of Prozac (as a replacement for Zoloft). 5mg/day sounds reasonable. You could ask your pdoc at your next appointment.
Love Ed xxx
Posted by willyee on May 31, 2005, at 17:31:48
In reply to Re: Nardil, the end of the story » Maxime, posted by ixus on May 31, 2005, at 11:43:29
> > Hey I have only ever responded to Prozac and Parnate as well.
> >
> Welcome in the club!
> Update: I started Parnate 10mg bid and I feel a huge relief.
> /ixus
Im telling you guys i think there is really something to taking parnate after stopping nardil,ive been keeping track and most people who do not wasout respond great to going back on parnate,for instance you felt a huge relief at 10 mg where id guess normaly 10 mg of parnate would not be much at all,in this case since its upon the stopping of nardil you responded,max was this ur case too......its almost as if nardil is setting up something or replacing something too much parnate is ruining....and after being on nardil a period of time,the parnate becomes like the first time you took it again,maybe im crazy but i see a pattern.
>
Posted by Phillipa on May 31, 2005, at 18:16:20
In reply to Re: Nardil, the end of the story, posted by willyee on May 31, 2005, at 17:31:48
Thanks Ed! I'll write it down as I have a tendency to forget things. Fondly, PJ O
Posted by ixus on May 31, 2005, at 23:28:53
In reply to Re: Nardil, the end of the story, posted by willyee on May 31, 2005, at 17:31:48
> Im telling you guys i think there is really something to taking parnate after stopping nardil,ive been keeping track and most people who do not wasout respond great to going back on parnate,for instance you felt a huge relief at 10 mg where id guess normaly 10 mg of parnate would not be much at all,in this case since its upon the stopping of nardil you responded,max was this ur case too......its almost as if nardil is setting up something or replacing something too much parnate is ruining....and after being on nardil a period of time,the parnate becomes like the first time you took it again,maybe im crazy but i see a pattern.
> >Hi,
Parnate dose is 20 in total. Btw I can agree with your point. My OCD will start as soon as MAO destroyed by Nardil are recovered. I don't want to mix 2 IMAO because Nardil makes me depressed anyway. OK, it was funny at the beginning, but 10 days after I was crying that my whole life was ruined. I could not even pack my things.
/ixus
Posted by ixus on May 31, 2005, at 23:47:17
In reply to Re: Nardil, the end of the story » ixus, posted by Phillipa on May 31, 2005, at 16:34:22
> Wait a minute! Talk english to me. Because when prozac first came out only in 20mg capsules my pdoc asked me to try it. The first day I wallpapered the foyer, the second day I was anxious, and the third day I was in total panic. I stopped taking the med and it took 3 days of xanax to come back to my very, at the time, functional working self. The pdoc said when I next saw him "please keep taking it you had such a dramatic response to it. Only take it every three days". Well I refused. So would this mean that prozac would be a good drug for me maybe in smaller doses? Fondly, Phillipa
>God knows. I doubt. I took 80mg of Prozac without any major side effects.
/ixus
This is the end of the thread.
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