Psycho-Babble Medication Thread 517970

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Fish oil issue

Posted by ed_uk on June 24, 2005, at 9:00:14

Fish Oil Supplementation and Risk of Ventricular Tachycardia and Ventricular Fibrillation in Patients With Implantable Defibrillators
A Randomized Controlled Trial

Merritt H. Raitt, MD; William E. Connor, MD; Cynthia Morris, PhD, MPH; Jack Kron, MD; Blair Halperin, MD; Sumeet S. Chugh, MD; James McClelland, MD; James Cook, MD; Karen MacMurdy, MD; Robert Swenson, MD; Sonja L. Connor; Glenn Gerhard, MD; Dale F. Kraemer, PhD; Daniel Oseran, MD; Christy Marchant, RN, MBA; David Calhoun, RN; Reed Shnider, MD; John McAnulty, MD

JAMA. 2005;293:2884-2891.

Context Clinical studies of omega-3 polyunsaturated fatty acids (PUFAs) have shown a reduction in sudden cardiac death, suggesting that omega-3 PUFAs may have antiarrhythmic effects.

Objective To determine whether omega-3 PUFAs have beneficial antiarrhythmic effects in patients with a history of sustained ventricular tachycardia (VT) or ventricular fibrillation (VF).

Design and Setting Randomized, double-blind, placebo-controlled trial performed at 6 US medical centers with enrollment from February 1999 until January 2003.

Patients Two hundred patients with an implantable cardioverter defibrillator (ICD) and a recent episode of sustained VT or VF.

Intervention Patients were randomly assigned to receive fish oil, 1.8 g/d, 72% omega-3 PUFAs, or placebo and were followed up for a median of 718 days (range, 20-828 days).

Main Outcome Measures Time to first episode of ICD treatment for VT/VF, changes in red blood cell concentrations of omega-3 PUFAs, frequency of recurrent VT/VF events, and predetermined subgroup analyses.

Results Patients randomized to receive fish oil had an increase in the mean percentage of omega-3 PUFAs in red blood cell membranes from 4.7% to 8.3% (P<.001), with no change observed in patients receiving placebo. At 6, 12, and 24 months, 46% (SE, 5%), 51% (5%), and 65% (5%) of patients randomized to receive fish oil had ICD therapy for VT/VF compared with 36% (5%), 41% (5%), and 59% (5%) for patients randomized to receive placebo (P = .19). In the subset of 133 patients whose qualifying arrhythmia was VT, 61% (SE, 6%), 66% (6%), and 79% (6%) of patients in the fish oil group had VT/VF at 6, 12, and 24 months compared with 37% (6%), 43% (6%), and 65% (6%) of patients in the control group (P = .007). Recurrent VT/VF events were more common in patients randomized to receive fish oil (P<.001).

Conclusion Among patients with a recent episode of sustained ventricular arrhythmia and an ICD, fish oil supplementation does not reduce the risk of VT/VF and may be proarrhythmic in some patients.

Redirect: Fish oil

Posted by Dr. Bob on June 25, 2005, at 10:28:12

In reply to Fish oil issue, posted by ed_uk on June 24, 2005, at 9:00:14

> Fish Oil Supplementation and Risk of Ventricular Tachycardia and Ventricular Fibrillation in Patients With Implantable Defibrillators

Sorry to interrupt, but I'd like to redirect this thread to Psycho-Babble Alternative. Here's a link:

http://www.dr-bob.org/babble/alter/20050612/msgs/518601.html

Thanks,

Bob

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