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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 12 of 12. This is the beginning of the thread.
Posted by iforgotmypassword on September 28, 2005, at 12:48:11
http://www.biopsychiatry.com/moclobemide-neogenesis.htm
here it says that NMDA is causing a decrease in some cells in the hippocampus... not that i can even close to know what that means. anyways, if the receptors are antagonized does this lead to higher amounts of circulating NMDA, so if there is a neurotoxic risk to the substance would NMDA antagonists potentiate it?
Posted by Shawn. T. on September 28, 2005, at 14:44:06
In reply to could NMDA antagonists have neurotoxic effects?, posted by iforgotmypassword on September 28, 2005, at 12:48:11
NMDA is a synthetic substance that isn't naturally present in your brain. If NMDA were applied to cells in your brain, an NMDA antagonist would decrease the toxicity induced by NMDA.
Shawn
Posted by Phillipa on September 28, 2005, at 18:40:37
In reply to Re: could NMDA antagonists have neurotoxic effects?, posted by Shawn. T. on September 28, 2005, at 14:44:06
So according to the link this is an MAOI? Fondly, Phillipa
Posted by Shawn. T. on September 28, 2005, at 18:52:24
In reply to Re: could NMDA antagonists have neurotoxic effects?, posted by Phillipa on September 28, 2005, at 18:40:37
Moclobemide is a selective and reversible inhibitor of monoamine oxidase type A (MAO-A).
Shawn
Posted by Phillipa on September 28, 2005, at 19:04:10
In reply to Re: could NMDA antagonists have neurotoxic effects? » Phillipa, posted by Shawn. T. on September 28, 2005, at 18:52:24
Thanks Shawn, but now I don't know what the differnce is between MAOI and A. Never knew there was another one. Trying to learn. Fondly, Phillipa
Posted by Shawn. T. on September 28, 2005, at 20:18:29
In reply to Re: could NMDA antagonists have neurotoxic effects? » Shawn. T., posted by Phillipa on September 28, 2005, at 19:04:10
MAOI stands for monoamine oxidase inhibitor. MAO-A is a type of monoamine oxidase. Some MAOIs inhibit both MAO-A and MAO-B. Moclobemide only inhibits the former. MAO-A catalyzes the oxidative deamination of monoamines such as serotonin, norepinephrine, and dopamine. Deamination is the removal of an amine group from a molecule. An amine group consists of nitrogen (and associated hydrogen atoms) attached to a carbon chain.
Shawn
Posted by Chairman_MAO on September 28, 2005, at 20:42:06
In reply to Re: could NMDA antagonists have neurotoxic effects?, posted by Shawn. T. on September 28, 2005, at 14:44:06
You are incorrect. NMDA stands for N-methyl-D-asparate, which is a glutaminergic neurotransmitter.
Posted by Phillipa on September 28, 2005, at 21:50:46
In reply to Re: could NMDA antagonists have neurotoxic effects?, posted by Shawn. T. on September 28, 2005, at 20:18:29
Are you both studying to be doctors, pharmacists, chemists? I just don't know where you guys get all your knowledge. Fondly, Phillipa
Posted by Shawn. T. on September 28, 2005, at 22:27:44
In reply to Shawn: NMDA is endogenous and a neurotransmitter » Shawn. T., posted by Chairman_MAO on September 28, 2005, at 20:42:06
NMDA is not a neurotransmitter. See http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract to verify that it is a synthetic rather than an endogenous substance.
Shawn
Posted by Shawn. T. on September 28, 2005, at 22:42:26
In reply to Re: could NMDA antagonists have neurotoxic effects?, posted by Phillipa on September 28, 2005, at 21:50:46
>>Are you both studying to be doctors, pharmacists, chemists? I just don't know where you guys get all your knowledge. Fondly, Phillipa
I'm pursuing a Master of Science degree in Library and Information Science from the University of Illinois at Urbana-Champaign. I want to improve the dissemination of information to people interested in fields such as neuroscience, psychiatry, and pharmacology. I was going to join a multidisciplinary neuroscience graduate program, but my approach to neuroscience was too multidisciplinary for them to swallow. The best way to acquire knowledge of neuroscience is to read peer-reviewed articles, regardless of whether you completely understand them. You should have a medical or biological dictionary handy while doing so. You'll catch on sooner or later if you're persistent.
Shawn
Posted by Phillipa on September 29, 2005, at 0:07:56
In reply to Re: could NMDA antagonists have neurotoxic effects? » Phillipa, posted by Shawn. T. on September 28, 2005, at 22:42:26
Shawn that's awesome. I'm gaining knowledge to help me understand what you all are talking about. Today I saw my doctor and he and I were dicussing AD's and I told him I was hypomanic on wellburin. I said it made me bipolar lll. He looked at me rather strangely. But I learned it here. And I've worked as a psych nurse and want to again. Can you imagine knowing more than the pdocs do? Fondly, Phillipa
Posted by SLS on September 29, 2005, at 8:12:35
In reply to Re: could NMDA antagonists have neurotoxic effects? » Phillipa, posted by Shawn. T. on September 28, 2005, at 22:42:26
Hi Shawn.
> I'm pursuing a Master of Science degree in Library and Information Science from the University of Illinois at Urbana-Champaign. I want to improve the dissemination of information to people interested in fields such as neuroscience, psychiatry, and pharmacology.
I really appreciate your efforts. You have already contributed much towards meeting this goal.
- Scott
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