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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by CK1 on November 12, 2005, at 11:07:17
My Nardil trial came to an end on Day 19 due to
1) Stiff lips and tongue
2) Facial twitch (unnoticeable)
3) Difficulty Speaking
and other bothersome side effects.I was taking Adderall with it. Nardil blocks the enzyme that breaks down dopamine and Adderall floods your brain with dopamine. Flooding your brain with dopamine from Adderall and being unable to break it down essentially means you are bathing in dopamine but cannot get it out of your system. It builds and builds until, in my case, a dystonic reaction occurs.
These reactions go away with time, but they are very scary. The twitch is gone, but the stiff, aching lips remain although it is getting better. It's only been 9 days since I quit Nardil so it's still in my system. I think it will take a few more weeks to get over this.
Nardil and Adderall IS NOT OK, no matter what anyone on this board says. Read this board with a grain a salt.....
Posted by gibber on November 12, 2005, at 12:00:38
In reply to Aderall and Nardil --- DO NOT DO THIS, posted by CK1 on November 12, 2005, at 11:07:17
> My Nardil trial came to an end on Day 19 due to
> 1) Stiff lips and tongue
> 2) Facial twitch (unnoticeable)
> 3) Difficulty Speaking
> and other bothersome side effects.
>
> I was taking Adderall with it. Nardil blocks the enzyme that breaks down dopamine and Adderall floods your brain with dopamine. Flooding your brain with dopamine from Adderall and being unable to break it down essentially means you are bathing in dopamine but cannot get it out of your system. It builds and builds until, in my case, a dystonic reaction occurs.
>
> These reactions go away with time, but they are very scary. The twitch is gone, but the stiff, aching lips remain although it is getting better. It's only been 9 days since I quit Nardil so it's still in my system. I think it will take a few more weeks to get over this.
>
> Nardil and Adderall IS NOT OK, no matter what anyone on this board says. Read this board with a grain a salt.....
Did your doctor allow you to take these together? Are you going to go back to nardil now that you know that the combo was causing the problems?
Posted by Schess81 on November 12, 2005, at 12:19:14
In reply to Aderall and Nardil --- DO NOT DO THIS, posted by CK1 on November 12, 2005, at 11:07:17
I combined 30mg Adderall XR with 10mg of Deprenyl a few times, didnt have a problem. The Deprenyl actually softend the amphetamine crash I often get.
Posted by WeeWilly on November 12, 2005, at 14:57:54
In reply to Aderall and Nardil --- DO NOT DO THIS, posted by CK1 on November 12, 2005, at 11:07:17
> My Nardil trial came to an end on Day 19 due to
> 1) Stiff lips and tongue
> 2) Facial twitch (unnoticeable)
> 3) Difficulty Speaking
> and other bothersome side effects.
>
> I was taking Adderall with it. Nardil blocks the enzyme that breaks down dopamine and Adderall floods your brain with dopamine. Flooding your brain with dopamine from Adderall and being unable to break it down essentially means you are bathing in dopamine but cannot get it out of your system. It builds and builds until, in my case, a dystonic reaction occurs.
>
> These reactions go away with time, but they are very scary. The twitch is gone, but the stiff, aching lips remain although it is getting better. It's only been 9 days since I quit Nardil so it's still in my system. I think it will take a few more weeks to get over this.
>
> Nardil and Adderall IS NOT OK, no matter what anyone on this board says. Read this board with a grain a salt.....YMMV! I am currently takeing, Nardil-45mg, Zyprexa-5mg(for insomnia), and 10mg Adderall prn.
Its been 5 weeks now and is finally becoming quite helpfull for my SP/Dysthymia. The side effects are diminishing.
The mode of action of all psychoactive meds is not known. Any theory that only addresses Dopamine, Seretonin and NE is absured. What about neurosteroids, steroids, cell growth in the amyglia, hpga axis changes, etc., etc..
We are still in the dark ages of mental health treatment. It seems to be inherant in most of us to understand what is amiss will our biochemistry. Unfortunately it cannot be understood at present. Best wishes!
Posted by Phillipa on November 12, 2005, at 21:18:50
In reply to Aderall and Nardil --- DO NOT DO THIS, posted by CK1 on November 12, 2005, at 11:07:17
Yikes CKl, I'll repeat the question was your doctor aware of the combination? Read my Babblemail to you. Love Phillipa
Posted by Tom Twilight on November 13, 2005, at 3:42:11
In reply to Aderall and Nardil --- DO NOT DO THIS, posted by CK1 on November 12, 2005, at 11:07:17
I'm sorry you had such a bad experience with this combination SK1
However I'm not sure if your right to conclude that the combination is a bad one for everyone, thats a fairly big assertion.
I would like to know what dosage of Adderall you took with your Nardil.
Adding a high dose stimulant onto an MAOI is obviously very dangerous!
As I always say 'Start Low, go Slow!'Even those who addivicate combining stimulants with MAOIs warn that it should be done very carefully.
I think a Stimulant can be combined with an MAOI if one is very careful.
Afterall Maxine was on Dexedrine and Parnate, and she never had a reaction (to the best of my knowlage)Having said all this I never tried combining a stimulant with Marplan, other than caffeine :)
So I'm no expert!Obviously its better to stay clear of stimulants if one is taking an MAOI, but for some people I think Stimulant+MAOI can be very helpfull, but please, please be carefull!
I should also point out that some stimulants are leffal with MAOIs, such as Ephedrine!
Here is a list of MAOI plus stimulant combos, provided by the lovely Maxine
http://www.dr-bob.org/babble/20050516/msgs/499763.html
Posted by Jedi on November 14, 2005, at 0:28:02
In reply to Aderall and Nardil --- DO NOT DO THIS, posted by CK1 on November 12, 2005, at 11:07:17
> Nardil and Adderall IS NOT OK, no matter what anyone on this board says. Read this board with a grain a salt.....
Hi CK1,
Augmentation of an antidepressant should only follow a full trial of the antidepressant itself. I have been taking Nardil for years and have never had any of the side effects that you attribute to Nardil. Everybody is different but when using an MAOI you must be careful to the point of researching everything you put in your system. As I mentioned before, I don't trust the word of laymen, pharmacists or MDs. Research, Research, Research ... Your life is in your hands.
Take care,
Jedi
Posted by jerrympls on November 16, 2005, at 0:16:35
In reply to Aderall and Nardil --- DO NOT DO THIS, posted by CK1 on November 12, 2005, at 11:07:17
> My Nardil trial came to an end on Day 19 due to
> 1) Stiff lips and tongue
> 2) Facial twitch (unnoticeable)
> 3) Difficulty Speaking
> and other bothersome side effects.
>
> I was taking Adderall with it. Nardil blocks the enzyme that breaks down dopamine and Adderall floods your brain with dopamine. Flooding your brain with dopamine from Adderall and being unable to break it down essentially means you are bathing in dopamine but cannot get it out of your system. It builds and builds until, in my case, a dystonic reaction occurs.
>
> These reactions go away with time, but they are very scary. The twitch is gone, but the stiff, aching lips remain although it is getting better. It's only been 9 days since I quit Nardil so it's still in my system. I think it will take a few more weeks to get over this.
>
> Nardil and Adderall IS NOT OK, no matter what anyone on this board says. Read this board with a grain a salt.....I agree stimulants and MAOIs should NOT be used together unless properly followed by your doctor. Why? Because There are cases where small amounts of stimulants like Adderall and Dexedrine can be added to MAOI therapy. How do I know? Because I was on Dexedrine & Naardil once and had no bad reactions.
However, I had a severe episode of serotonin syndrom that wound me up in the ICU for a day after I took some cough medicein that contained dextromethorphan. Dextro has a serotonin reuptake inhibitor action. 10 minutes after I took the cough medicine, I began shaking uncontrollably and violently. The medics from the Ambulance could hardly keep me held down. The doctors put me on an IV of ativan and periactin (which reverses serotonin reuptake inhibition) and within an hour or two I was fine. However, they kept me over night because they were worried I may have had kidney damage - which fortunately I didn't.
Jerry
This is the end of the thread.
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