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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by Michael Bell on February 25, 2006, at 23:06:36
The metabolite of phenelzine (Nardil) that increases the levels of Gaba in the brain by inhibiting Gaba Transanimase is called Phenylethylidenehydrazine (PEH). Like phenelzine, it inhibits Gaba-T but does not affect MAO. According to the links below, PEH should be investigated as a viable alternative for anti-anxiety by raising gaba levels.
http://en.wikipedia.org/wiki/Phenelzine
http://www3.interscience.wiley.com/cgi-bin/abstract/87510653/ABSTRACT
Anyone have more info on this? Thanks.
Posted by Tom Twilight on February 27, 2006, at 3:57:54
In reply to GABA-T inhitbitor: alternative to Nardil, posted by Michael Bell on February 25, 2006, at 23:06:36
Hey Mike
Glad to see someones still thinking "Outside the Box" (if you'll pardon the expression) on this board!
I'm very interested in GABA-T inhibitors, especially Phenylethylidenehydrazine (PEH)
Unfortunatly I haven't heard anything new on it for a while (sigh)
There are lots of GABA-T inhibitors out there, look under research chemicals.
Chairman MAOI is really your man for (PEH), don't know were he is now.
Posted by Chairman_MAO on March 1, 2006, at 11:36:53
In reply to GABA-T inhitbitor: alternative to Nardil, posted by Michael Bell on February 25, 2006, at 23:06:36
It looks great on paper, and my organic chemist friend said the synthesis they give is trivial, i.e. just about anyone could do it with some brains, basic equipment, and the requisite chemicals. It is a better GABA-T inhibitor than either valproate or gamma-vinyl-gaba.
I highly doubt this will ever be developed into a drug. I spend a lot of time researching GABA-T inhibitors & natural GABAnerigcs. The drug gastrodin from gastrodia elata tuber extract is one of the best you might be able to get your hands on.
Vanillin (the flavoring) is a GABA-T inhibitor. Many, many things you would never expect are GABAnergic. Thymol, the anesthetic in listerine, has positive GABA(A) activity. Think about that, keeping in mind there is ethanol in there as well....anyone eat lots of cheap vanilla ice cream and then wash their mouth compulsively with listerine?
I think it would be just as effective and take less effort to get a script for a downer.
BTW I may be wrong, but phenelzine isn't a GABA-T inhibitor. PEH is a metabolite of PLZ, and thus that's why PLZ is said to have a GABAnergic effect.
Posted by Lamdage22 on June 8, 2018, at 8:04:26
In reply to Re: GABA-T inhitbitor: alternative to Nardil, posted by Chairman_MAO on March 1, 2006, at 11:36:53
How can i get Gaba-T Inhibition??
Can a doctor here in Germany prescribe an metabolite of an american Antidepressant "Nardil"?
Posted by sigismund on June 23, 2018, at 1:30:15
In reply to Re: GABA-T inhitbitor: alternative to Nardil, posted by Chairman_MAO on March 1, 2006, at 11:36:53
Gastrodin has never done much for me.
I mucked around with the dosage, three times what was on the label. IDK, maybe not enough?
This is the end of the thread.
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