![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by ed_uk on March 31, 2006, at 16:20:35
Another cut and paste job by Ed.........
From the Phamaceutical Journal........
Use of selective serotonin reuptake inhibitors is associated with a reduced risk of colorectal cancer, according to researchers in Canada (Lancet Oncology 2006;7:301). No consistent relationship between tricyclic antidepressants and risk of colon cancer was observed, they add.
Wanning Xu, McGill University, Montreal, Quebec, and colleagues conducted a population-based, nested case-control study. The SSRI population consisted of 3,367 cases and 13,468 controls and the tricyclic antidepressant population consisted of 6,544 cases and 26,176 controls.
Animal studies have previously suggested that SSRIs reduce the growth of colorectal cancer and that tricyclic antidepressants enhance carcinogenesis in the colon, the researchers explain. They therefore aimed to assess whether SSRI use was associated with a decreased risk of colorectal cancer and tricyclic use with an increased risk of colorectal cancer.
The researchers found that a decreased risk of colorectal cancer was associated with high daily SSRI intake 0–5 years before diagnosis, adjusted for sex, age, use of non-steroidal anti-inflammatory drugs and use of SSRIs during 6–10 years before diagnosis (incidence rate ratio 0.70, 95 per cent confidence interval 0.50–0.96; P for trend=0.0172). They suggest that SSRIs may have antipromoter or direct cytotoxic effects. No significant association between risk of colorectal cancer and use of any tricyclic antidepressant was recorded, they add.
Possible causes of colorectal cancer, such as unhealthy lifestyle and diet, were not adjusted for, say the researchers. “Future studies should have a more complete assessment of confounders, including lifestyle and dietary habits, use of other drugs such as statins and the presence of comorbidity such as diabetes and inflammatory bowel disease,” they suggest.
The author of an accompanying editorial (ibid, p277) comments that the data provide interesting insights but, until further trial data are available, clinicians should not consider SSRI use solely for chemopreventive purposes.
Posted by Glydin on March 31, 2006, at 18:03:07
In reply to SSRIs may reduce risk of colon cancer, posted by ed_uk on March 31, 2006, at 16:20:35
SOMETHING positive about SSRI's.
You want to take odds someone will... okay, never mind, what I would post not be particularly civil.
Posted by Phillipa on March 31, 2006, at 21:32:09
In reply to Thank Goodness » ed_uk, posted by Glydin on March 31, 2006, at 18:03:07
He He Glydin!!!!!!!Love Phillipa
Posted by yxibow on April 1, 2006, at 0:24:13
In reply to Re: Thank Goodness » Glydin, posted by Phillipa on March 31, 2006, at 21:32:09
> He He Glydin!!!!!!!Love Phillipa
Actually at least two of the "George Carlin Seven Dirty Words" were considered proper English until around the Victorian era when they were replaced with more medical sounding terminology as proper language.
Colon cancer however is no joke. Fiber, fiber.
Tidings :)
-- Jay
Posted by ed_uk on April 1, 2006, at 12:42:24
In reply to Thank Goodness » ed_uk, posted by Glydin on March 31, 2006, at 18:03:07
Hi G
I think it's important to try to develop a balanced view of psych drugs.
Ed
Posted by minimal on April 1, 2006, at 13:24:09
In reply to SSRIs may reduce risk of colon cancer, posted by ed_uk on March 31, 2006, at 16:20:35
Someone close to me developed colon cancer after 8-10 years on Prozac. They were reasonably healthy, non-drinker, non-smoker, and under 50. In fact, once discovered in 2001, the doctors said the cancer had been growing for around 7-8 years, or shortly after the period of SSRI use began. Although, admittedly, the cancer could have come from a variety of factors, it seems equally possible that it could have been brought on by SSRI use.
It does not have to be that the active chemicals in SSRI's are themselves cancerous. It could just be a matter of constipation produced by the drug.In fact, as stated, frequent bowel movements and a high fiber diet are apparently key to reducing chances of colon cancer. If anything, given the common Prozac side effect of constipation, it would seem to only contibute to higher levels of colon cancer.
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.