![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by Sarah T. on April 1, 2006, at 1:26:30
I know that it can be very difficult to combine TCAs with other meds. Does anyone know which TCA is LEAST likely to cause adverse interactions with other medications? I'm thinking mostly in terms of cytohrome P450 interactions, but in my experience, going by those cytochrome charts isn't always the most reliable indicator. As so often happens, I usually have to resort to trial and error. What has your experience been?
Posted by ed_uk on April 1, 2006, at 13:36:15
In reply to Which TCA LEAST likely to cause drug interactions, posted by Sarah T. on April 1, 2006, at 1:26:30
Hi Sarah
>Which TCA LEAST likely to cause drug interactions?
Interactions with which meds?
Ed
Posted by Phillipa on April 1, 2006, at 20:06:54
In reply to Which TCA LEAST likely to cause drug interactions, posted by Sarah T. on April 1, 2006, at 1:26:30
Sarah you better answer quick as Ed is working six days a week and not here much. Love Phillipa
Posted by Sarah T. on April 2, 2006, at 0:34:25
In reply to Re: Which TCA LEAST likely to cause drug interactions » Sarah T., posted by ed_uk on April 1, 2006, at 13:36:15
> Hi Sarah
>
> >Which TCA LEAST likely to cause drug interactions?
>
> Interactions with which meds?> EdHi Ed.
Thanks so much for your time. Phillipa tells me you are very much in demand these days!!I am not refering to a particular med. It was just a general question. I have extreme difficulty with med combos. In the past, when I've been on ADs and have had to take anything else, even an antibiotic, I have to stop the AD's while I'm on the other meds. So, I was just wondering in a general sense for future reference. I'm pretty sure that the TCAs have a lot of potential interactions due to the fact that most of them affect multiple cytochromes. I've had so much difficulty that even meds that aren't documented to actually inhibit some cytochomes still cause severe interections, possibly because both meds might be substrates of the same enzymes and, therefore, compete with each other. Sheldon Preskorn says that we know only about 20% of what there is to learn about drug interactions and liver enzymes. I think that's probably an understatement. Often, I have had severe adverse reactions from med combos for which there was absolutely no documented contraindication.
Sarah
Posted by Sarah T. on April 2, 2006, at 0:35:44
In reply to Re: Which TCA LEAST likely to cause drug interactions » Sarah T., posted by Phillipa on April 1, 2006, at 20:06:54
Posted by ed_uk on April 2, 2006, at 13:53:53
In reply to Re: Which TCA LEAST likely to cause drug interactions, posted by Sarah T. on April 2, 2006, at 0:34:25
Hi Sarah
>Sheldon Preskorn says that we know only about 20% of what there is to learn about drug interactions and liver enzymes. I think that's probably an understatement.
I agree!
I don't know of any TCA which is associated with less drug interactions in general - although specific TCAs may be particularly problematic in specific situations.
Regards
Ed
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.