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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by JaclinHyde on April 1, 2006, at 1:47:45
Sigh...guess what I found?
"Drug Interactions:
Trazodone may enhance the response to alcohol and the effects of barbiturates and other CNS depressants and patients should be cautioned accordingly.Increased serum digoxin and phenytoin levels have been reported to occur in patients receiving trazodone concurrently with either of those 2 drugs. Little is known about the interaction between trazodone and general anesthetics; therefore, prior to elective surgery, trazodone should be discontinued for as long as clinically feasible.
****Because it is not known whether an interaction will occur between trazodone and MAO inhibitors, administration of trazodone should be initiated very cautiously with gradual increase in dosage as required, if an MAO inhibitor is given concomitantly or has been discontinued shortly before medication with trazodone is instituted.****
(And Tyler.....)
*****Trazodone may cause hypotension including orthostatic hypotension and syncope; caution is required if it is given to patients receiving antihypertensive drugs and an adjustment in the dose of the antihypertensive medication may be required.*****
Ambien CR has just become my new best friend :-)
JH
Posted by yxibow on April 1, 2006, at 12:26:34
In reply to MAOI interaction with Trazodone, posted by JaclinHyde on April 1, 2006, at 1:47:45
> Sigh...guess what I found?
>
> "Drug Interactions:
> Trazodone may enhance the response to alcohol and the effects of barbiturates and other CNS depressants and patients should be cautioned accordingly.
>
> Increased serum digoxin and phenytoin levels have been reported to occur in patients receiving trazodone concurrently with either of those 2 drugs. Little is known about the interaction between trazodone and general anesthetics; therefore, prior to elective surgery, trazodone should be discontinued for as long as clinically feasible.
>
> ****Because it is not known whether an interaction will occur between trazodone and MAO inhibitors, administration of trazodone should be initiated very cautiously with gradual increase in dosage as required, if an MAO inhibitor is given concomitantly or has been discontinued shortly before medication with trazodone is instituted.****
>
> (And Tyler.....)
>
> *****Trazodone may cause hypotension including orthostatic hypotension and syncope; caution is required if it is given to patients receiving antihypertensive drugs and an adjustment in the dose of the antihypertensive medication may be required.*****
>
> Ambien CR has just become my new best friend :-)
:) And a much better sleep aid, or Lunesta, up to 3 mg/dy. I believe in REM promoting, pure sleep aids.You can also check, which mentions this interaction in bold red, at
http://www.drugs.com/drug_interactions.html
You just click yes on the legalese and then go enter all your medications one by one and see if there are especially any red marks. Its not perfect but its one of the better ones out there
Posted by JaclinHyde on April 5, 2006, at 3:19:18
In reply to Re: MAOI / Trz Checking Drug Interactions Online » JaclinHyde, posted by yxibow on April 1, 2006, at 12:26:34
That's a great one. My favorite link is from Medscape becaue in my book their word is law.
http://www.medscape.com/druginfo/druginterchecker?cid=med&monotype=druginteractions&drugid=&drugname=
Here is the pertinent info from the drugs.com interaction database."trazodone and tranylcypromine (major Drug-Drug)
Description:
CONTRAINDICATED: Monoamine oxidase inhibitors (MAOIs) may potentiate the activity of serotonergic agents such as serotonin reuptake inhibitors, 5-HT1 receptor agonists, ergot alkaloids, buspirone, dextromethorphan, and most antidepressants. The result may be an increased risk of serotonin syndrome, which is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5HT1A receptors and characterized by CNS irritability, altered consciousness, confusion, myoclonus, ataxia, abdominal cramping, hyperpyrexia, shivering, pupillary dilation, diaphoresis, hypertension, and tachycardia. The mechanism is an additive pharmacodynamic effect resulting from MAOI inhibition of serotonin metabolism.MANAGEMENT:
In general, serotonergic agents should not be used concurrently with MAOIs or other agents which possess MAOI activity (e.g., furazolidone, procarbazine, selegiline). At least 14 days should elapse between discontinuation of MAOI therapy and initiation of treatment with serotonergic agents. A washout period of 7 to 14 days minimum is recommended when switching from another antidepressant to an MAOI."JH
This is the end of the thread.
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