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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by Tom Twilight on December 14, 2006, at 1:55:37
This article is quite depressing!
Looks like were stuck with the lovely SSRIs for the forseable future :(
Hope its wrong!
By the way it comes from a really interesting website that I keep meaning to post.
The Sight is called "Anxiety Insights"
Has lots of up to date news on research!http://www.anxietyinsights.info/constrained_antidepressant_market_forecast.htm
Posted by SLS on December 14, 2006, at 6:28:47
In reply to New Drug Development-Bad News?, posted by Tom Twilight on December 14, 2006, at 1:55:37
> This article is quite depressing!
>
> Looks like were stuck with the lovely SSRIs for the forseable future :(
>
> Hope its wrong!
>
> By the way it comes from a really interesting website that I keep meaning to post.
>
> The Sight is called "Anxiety Insights"
> Has lots of up to date news on research!
>
> http://www.anxietyinsights.info/constrained_antidepressant_market_forecast.htm
I find some reason to have hope here:http://neurotransmitter.net/newdrugs.html
- Scott
Posted by tensor on December 14, 2006, at 10:36:27
In reply to Re: New Drug Development-Bad News?, posted by SLS on December 14, 2006, at 6:28:47
Good page, Scott. There's alot of interesting substances on the horizon. A couple of DA/NE/5-HT reuptake inhibitors and 5HT1A agonists and Organon seems to have a successor of Remeron in trial.
/Mattias
Posted by Phillipa on December 14, 2006, at 11:19:49
In reply to Re: New Drug Development-Bad News? » SLS, posted by tensor on December 14, 2006, at 10:36:27
I'm afraid it will be too late for me. Age wise. Love Phillipa
Posted by Tom Twilight on December 14, 2006, at 11:43:58
In reply to Re: New Drug Development-Bad News? » SLS, posted by tensor on December 14, 2006, at 10:36:27
> Good page, Scott. There's alot of interesting substances on the horizon. A couple of DA/NE/5-HT reuptake inhibitors and 5HT1A agonists and Organon seems to have a successor of Remeron in trial.
>I'm not sure about 5HT1A Agonists-I think they might not be all there hyped up to be
Hopefully I'm wrong :)The Triple Re-uptake inhibitors & Mirtazapine Matabolite sound more interesting.
Hopefully some NVK Antagonists will come out at some point.
I know some European Companies are working on interesting Compounds!
Any idea what happened to Seranductant?
Posted by saturn on December 14, 2006, at 11:45:34
In reply to Re: New Drug Development-Bad News? » SLS, posted by tensor on December 14, 2006, at 10:36:27
>>>Organon seems to have a successor of Remeron in trial.
I'm really interested in that one too (ORG 4420). It would be nice if it had less sedation and appetite issues than Remeron(due to less histamine receptor blockade?).
Posted by dessbee on December 14, 2006, at 13:51:23
In reply to Re: New Drug Development-Bad News?, posted by SLS on December 14, 2006, at 6:28:47
Great site.
I am really hoping on the CRF(1) receptor antagonists.
http://www.biopsychiatry.com/crf1-antagonists.htm
This could actually be a good investment list ;-)
Posted by SLS on December 14, 2006, at 14:02:27
In reply to Re: New Drug Development-Bad News? » SLS, posted by dessbee on December 14, 2006, at 13:51:23
> Great site.
>
> I am really hoping on the CRF(1) receptor antagonists.
>
> http://www.biopsychiatry.com/crf1-antagonists.htm
>
> This could actually be a good investment list ;-)I didn't realize they had actually tried CRF(1) receptor antagonists on people. The results seem encouraging.
- Scott
Posted by SLS on December 14, 2006, at 14:06:57
In reply to New Drug Development-Seranductant?, posted by Tom Twilight on December 14, 2006, at 11:43:58
> I'm not sure about 5HT1A Agonists-I think they might not be all there hyped up to be
> Hopefully I'm wrong :)By themselves, perhaps not. However, they might make good augmentors - sort of like Buspar without the dopamine receptor blockade. Also, the metabolite (1-PP) of gepirone acts like Remeron in that it is a NE alpha-2 receptor antagonist. I don't care under what pretenses it becomes available. It would be one more tool to work with.
- Scott
Posted by dessbee on December 14, 2006, at 14:46:17
In reply to Re: New Drug Development-Bad News? » dessbee, posted by SLS on December 14, 2006, at 14:02:27
Hopefully, CRF(1) receptor antagonists will stop a crazed HPA-axis without too many side-effects.
This is the end of the thread.
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