![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by Mishal on September 10, 2007, at 4:24:41
An Observation:
I have been on oral selegiline 15mg for the past four weeks. Now I can really feel the difference. My verbal communication has much improved along with a sense of "brain functioning normally"
Don't get surprised: I am taking selegiline with 40 mg of prozac and 100mg of sulpiride. I wish to up the selegiline dose to 20mg, but some posters here have already scared the hell out of me. Can anyone make it clear for myself; selegiline will be safe to me at 20mg if I go down with Prozac? I mean 20mg of Prozac and the same amount of Selegiline?
Posted by cumulative on September 10, 2007, at 17:11:17
In reply to Selegiline: excellent brain functioning!, posted by Mishal on September 10, 2007, at 4:24:41
No, no one can in good faith answer you that in the affirmative. There have been fatal interactions between fluoxetine and MAOIs: combinations of SSRI and MAO-A can be a bad, bad thing. Considering that selegiline eventually inhibits more and more of MAO-A will consistent dosing, I'd be damn careful.
I wonder though if full MAOI doses of selegiline (e.g. by the patch) would work as well as prozac does for you.
Posted by Meagan on September 11, 2007, at 15:50:05
In reply to Selegiline: excellent brain functioning!, posted by Mishal on September 10, 2007, at 4:24:41
I am taking 40 mg prozac and my pdoc just prescribed selegiline (5mg for one week, then up to 10 mg second week); he said that selegiline in small doses is okay to combine with prozac; in fact it is frequently done for people with Parkinson's disease. I am hoping I will have the good results you seem to be having.
Before you experiment with taking more selegiline, just check with your doctor; I think the concern is that taking too much of an MAOI with SSRI can cause risk of serotonin syndrome.
Posted by Sigismund on September 11, 2007, at 19:05:59
In reply to Selegiline: excellent brain functioning!, posted by Mishal on September 10, 2007, at 4:24:41
If I was also taking Prozac, I would want to keep the dose of selegeline down to 10mg/d or less.
Probably a good idea to familiarise yourself with the symptoms of serotonin syndrome too.
Posted by Meagan on September 12, 2007, at 8:34:21
In reply to Re: Selegiline: excellent brain functioning!, posted by Sigismund on September 11, 2007, at 19:05:59
Sigismund,
You are absolutely right about keeping the dose down to 10 mg or less when taking with prozac and yes my pdoc has alerted me to symptoms of serotonin syndrome. I took 5 mg last night and got an immediate lift today (starting to clean and organize my "stuff") and planning to go to the gym again soon.
I hope it continues to work without any nasty SEs.
Meagan
Posted by deniseuk190466 on September 16, 2007, at 15:45:40
In reply to Selegiline: excellent brain functioning!, posted by Mishal on September 10, 2007, at 4:24:41
Hi,
I think it's great that you've found relief with this combination and that you have a psychiatrist who was willing to push the boat a litte and try something like that. I imagine if I mentioned a combination of an SSRI and Selegiline to any of the psychiatrists I've seen (on the NHS anyway) they would look at me horrified.
I have however seen a few people who have reported good results with this combination. I've also read that low dose selegeline acts a bit like amphetamine.
I hope this continues to work for you.
Denise
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.