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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by JayBTV2 on October 1, 2007, at 9:10:23
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=15013050
The study was done to see how much and at what doses Depakote inhibits the half-life of Lamictal. From what I can make of it the inhibition is the same if you're taking 250mg of depakote or 500mg of depakote with lamictal.
Is that correct based on the results in the study? Just want to be sure since I recently lowered my Depakote from 500 to 250. Hopefully that didn't change my Lamictal levels....
Thanks!
-Jay
Posted by JayBTV2 on October 1, 2007, at 9:12:24
In reply to Please help interpret the this pubmed study...., posted by JayBTV2 on October 1, 2007, at 9:10:23
Sorry for the "the this" typo in the title :)
Posted by Larry Hoover on October 1, 2007, at 11:08:09
In reply to Please help interpret the this pubmed study...., posted by JayBTV2 on October 1, 2007, at 9:10:23
> http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=15013050
>
> The study was done to see how much and at what doses Depakote inhibits the half-life of Lamictal. From what I can make of it the inhibition is the same if you're taking 250mg of depakote or 500mg of depakote with lamictal.
>
> Is that correct based on the results in the study?According to the data included in the abstract, you're correct. However, the authors reach an improper conclusion, when they say:
"Importantly, maximal inhibition can be expected at VPA doses of approximately 500 mg per day, with the magnitude of inhibition diminishing at doses below this."
In fact, their data suggest a threshold for maximal inhibition at, or below, 250 mg/day.
One must always remember, however, that these are mean data. Without access to the entire dataset, you can't know how variable was the individual response.
Lar
Posted by JayBTV2 on October 1, 2007, at 14:27:53
In reply to Re: Please help interpret the this pubmed study.... » JayBTV2, posted by Larry Hoover on October 1, 2007, at 11:08:09
Thanks for the insight!!
This is the end of the thread.
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