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Dr. Bob is Robert Hsiung, MD,
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Posted by medweirdo on October 7, 2007, at 6:58:22
I've being researching Nardil latterly and couldn't understand where does nardil take place in the brain. I mean whether it elevates monoamines at the presynaptic neurons or postsynapric neurons or just in neurons' gaps (between presynaptic and postsynapric)???.
I found a nice picture showing the mechanism of antidepressants here:
http://www.cmaj.ca/content/vol168/issue ... 28ff1.jpeg
as I see it ssri's block presynaptic neurons at uptake's gate but am still cunfused with maoi's.
Posted by Racer on October 7, 2007, at 12:44:37
In reply to Where does Nardil take place in the brain?, posted by medweirdo on October 7, 2007, at 6:58:22
Nardil doesn't so much "take place" at any given site in the brain, it inhibits the production of Monoamine Oxydase, the chemical which breaks down the catecholamine neurotransmitters, so that they all stick around longer.
This effect takes place throughout the body, so it is as true for the digestive tract as it is for the brain -- the serotonin in your gut is hanging around, just as the serotonin in your brain.
Hope that helps.
Posted by medweirdo on October 8, 2007, at 10:16:11
In reply to Re: Where does Nardil take place in the brain?, posted by Racer on October 7, 2007, at 12:44:37
Thanks... I've found a very informative site which explain mechanism of every class of drugs including maoi's here:
http://images.google.co.il/imgres?imgurl=http://www.cnsforum.com/content/pictures/imagebank/thumbs/Drug_SSRI_2.gif&imgrefurl=http://www.cnsforum.com/imagebank/section/Antidepressants/default.aspx&h=146&w=145&sz=11&hl=iw&start=24&um=1&tbnid=8Q8tKonolz_B8M:&tbnh=95&tbnw=94&prev=/images%3Fq%3Dmaoi%2Bmechanism%26start%3D20%26ndsp%3D20%26svnum%3D10%26um%3D1%26hl%3Diw%26sa%3DN
This is the end of the thread.
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