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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by Jimmyboy on November 4, 2007, at 21:11:02
This article is kind of old, but I thought it was very interesting.
http://www.biopsychiatry.com/immunesystem/index.html
I have gotten off of most of my prescription meds recently by taking GLA supplements and the supporting vitamins that help make more Prostaglandin E 1 ( an anti-inflammatory ) - and feeling much better in a short period of time also!)Also of note is that Lithium markedly reduces the level of Prostaglandin E2 ( which is pro-inflammatory) - seems like there is a connection to me.
If anyone has any thoughts on the matter, I would love to hear them.
JB
Posted by Phillipa on November 4, 2007, at 22:33:33
In reply to Chronic Inflammation theory of depression, posted by Jimmyboy on November 4, 2007, at 21:11:02
Boy this could raise some debate as I have autoimmune diseases from an overactive immune system the opposite of a depressed one. Before it showed up with hasimotos thyroiditis I was fully working up to more than capacity but it beat me down even with the synthroid. But yet before that went through divorces and my Son's loss of eyesight in Desert Storm and I handled it all well no problems continued working. So which came first chicken or egg? And wierd but noticed that ibuphophen at night and I feel better the next day. All bloodwork normal except ANA and thyroid. Wonder if this is where a med like deplin comes in? Maybe? I don't know. What do you think? Phillipa
Posted by rvanson on November 4, 2007, at 23:39:29
In reply to Chronic Inflammation theory of depression, posted by Jimmyboy on November 4, 2007, at 21:11:02
>
> If anyone has any thoughts on the matter, I would love to hear them.No thoughts except that there seem to be multiple reasons why some people become depressed and this is another avenue to explore as about 20 % of AD patients have a very poor responce to traditional treatments.
Posted by BetterDays on November 5, 2007, at 15:15:38
In reply to Chronic Inflammation theory of depression, posted by Jimmyboy on November 4, 2007, at 21:11:02
Hi Jimmyboy,
The article was a bit over my head, but am interested in your comment on Lithium and Prostaglandin E2. Are you saying that Lithium reduces the levels of Prostaglandin E2 which is a natural anti inflammatory? Interestingly enough, the pain in my shoulder that I have from arthritis seems to be a lot worse since I started Lithium a couple of weeks ago. I chalked it up to coincidence.
Posted by d0pamine on November 5, 2007, at 16:07:39
In reply to Chronic Inflammation theory of depression, posted by Jimmyboy on November 4, 2007, at 21:11:02
Good stuff!!
Posted by d0pamine on November 5, 2007, at 19:25:50
In reply to Chronic Inflammation theory of depression, posted by Jimmyboy on November 4, 2007, at 21:11:02
So we have the theory that inflammation is the root cause of (some) depression. To add to that, here is what I found to be an incredibly interesting article about Intra cellular parasites being the root cause of inflammation. http://www.ra-infection-connection.com/macrophages.htm
This article speaks of the "Marshall Protocol", which is a three phase protocol for eliminating the parasites at the root of the infection that causes the inflammation that results in depression (at least apparently in some cases). Interestingly enough, the Marshall protocol uses the Angiotensin Receptor Blocker, Benicar to blockade the Angiotensin II receptors in the inflamed tissue to weaken the bacteria to the point that it can be killed. This also happens to be the very same Med that I attempted to use to control my bloodpressure, but stopped because it resulted in a very aggravating inflammation in pretty much every joint in my body. I think this may have been the arisch-Herxheimer reaction part of the inflammation cascade that is referenced in the article. I suppose I'm starting to ramble, so to cut it short, I've started the Marshall Protocol today and we'll see how it goes.Anyway, thanks Jimmyboy for posting this incredibly fascinating information and pulling some pieces together for me where I hadn't quite yet seen the connection. BTW Had you posted it in the alternative board, I would have never seen it as this is the only board I check. But hopefully since the Marshall protocol references a cocktail of prescription medications (including Benicar, and Minocycline) this thread now has enough relevance to this board to keep from being redirected. One more thing that I wanted to note is that I have found (as noted in the article) that vitamin D does indeed increase my inflammation (in spite of what one would expect)
Posted by Phillipa on November 5, 2007, at 19:49:50
In reply to Re: Chronic Inflammation theory of depression, posted by d0pamine on November 5, 2007, at 19:25:50
I was told this happened to me when being given rocephin through a pic line with chronic lymes disease that the quivering of muscles was the bacteria being destroyed. ANA at the time was 2880 to one so they couldn't decide whether it was autoimmune or the bacteria of lymes being destroyed. The syndrome is the one the infection control specialist decided on. Phillipa
Posted by Jimmyboy on November 7, 2007, at 12:19:27
In reply to Re: Chronic Inflammation theory of depression, posted by d0pamine on November 5, 2007, at 19:25:50
D0p ,
I also found your article very interesting, the idea of parasites --> inflammation--> depression is interesting, and if that is the case treating the cause , namely parasites, would be the smartest way to go. Since I am having success with my current regimen, I think I am going to stick with that, but I am very vey interested in how the "Marshall Protocall" works for you b/c I may try that myself one day. Good luck and keep us posted.
JB
Posted by Lonely on November 8, 2007, at 0:23:20
In reply to Re: Chronic Inflammation theory of depression » d0pamine, posted by Jimmyboy on November 7, 2007, at 12:19:27
Hmmm, wonder if it relates to inflammatory arthritis too?
This is the end of the thread.
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