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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by tootercat on July 8, 2008, at 15:45:40
I stopped Budeprion and started taking Brand name Wellbutrin and life is better!
No more anxiety and not being able to take my correct dosage of 150 SR twice daily. I can even go to sleep most nights without taking my 1 mg lorazepam. I don't feel hopeless, and irritable and even more depressed as I did while taking the impostor.
There IS a DIFFERENCE!
Posted by Phillipa on July 8, 2008, at 18:12:12
In reply to OMG What a difference! REAL Wellbutrin not generic, posted by tootercat on July 8, 2008, at 15:45:40
Hi Tootercat long time no write but seriously I also believe there are differences in generics of some meds than namebrand glad your back to feeling better. Phillipa
Posted by iforgotmypassword on July 9, 2008, at 8:52:45
In reply to OMG What a difference! REAL Wellbutrin not generic, posted by tootercat on July 8, 2008, at 15:45:40
what could be causing that sort of difference?
any experts?
Posted by Racer on July 9, 2008, at 10:48:41
In reply to how is this possible?, posted by iforgotmypassword on July 9, 2008, at 8:52:45
> what could be causing that sort of difference?
>
> any experts?I am not an expert, but -- wait, no, I don't even play one on TV...
The laws governing generics say that they have to be bioequivalent to within 10% of the name brand. Usually that means different -- id est: cheaper -- binders and fillers. The 10% figure is mostly a generic-to-generic issue, since that means two generics could conceivably differ by up to 20%. The bigger problem is the binders and fillers can cause odd reactions -- I'm listed in my GP's records as allergic to Prozac, because I had an allergic reaction to one particular generic.
In the case of the extended release versions of medications, my guess is that the release mechanism may be part of the problem with the generics. It might be that the medication isn't being released as reliably, or that something in the binder is interfering with absorption.
For whatever it's worth, the Budeprion is apparently problematic enough that many psychopharmacologists around here simply specify on ALL their prescriptions to fill with name brand Wellbutrin. I know that mine keeps me on a dose that requires the name brand -- 450mg, three 150mg per day.
It's supposed to be equivalent, but that doesn't always work out as well in practice...
Hope that helps..
Posted by atmlady on July 9, 2008, at 20:30:53
In reply to how is this possible?, posted by iforgotmypassword on July 9, 2008, at 8:52:45
I heard it had something to do with the time release mechanism not working right in the generic version. Whatever it is, I can testify that there is FOR CERTAIN something not right about generic wellbutrin, whatever the manufacturer. I've taken every version and the generic always makes me rabidly angry - as in throwing things around - this is SO not me, nor how I would respond with brand wellbutrin. I thought it was just my imagination until I read posts from others.
Posted by ihatedrugs on July 10, 2008, at 23:24:59
In reply to how is this possible?, posted by iforgotmypassword on July 9, 2008, at 8:52:45
> what could be causing that sort of difference?
>
> any experts?I don't know but I too did notice a marked difference between WB generic and name brand. My Pdoc writes on my prescription "name brand only".
Posted by Marty on July 17, 2008, at 15:41:21
In reply to Re: how is this possible?, posted by ihatedrugs on July 10, 2008, at 23:24:59
That reminds me the 'Old Nardil vs New Nardil' crisis. I'm no expert, but I suspect there's some truth into this story. I tried the New Nardil (probably the one from LINK PHARMA) and I NEVER saw pills smelling and tasting so awfully bad.. it was kind of rotten.. you were able to see at which kind of quality standard the new Nardil was subject to .... I guess 30,000 people takin Nardil in the world was enough for them to care./\/\arty
This is the end of the thread.
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