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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by RMFlorida on November 10, 2009, at 8:38:27
I'm interested in trying L-Dopa (along with B6) for purposes of its use as a dopamine precusor.
I've noticed that the dosage in OTC nutrients varies significantly. For example, it's used in some 'brain supplement' mixes, as low as 1-2mg (standardized). However, there are supplements that contain as much as 100 - 250mg (standardized) per tablet.
Can anyone tell me at what level the average person might notice the effects of taking L-Dopa, and whether there is an issue with build-up/an amount I should not be taking daily?
Could I also solicit opinions of others here, as to your experiences with L-Dopa, or opinions/feedback on whether there are better options for the intended purpose?
For example, I'm taking Tyrosine now. L-Dopa felt like it would be a more effective option of achieving the ultimate end-goal of increasing Dopamine, which is the reason for this line of thinking.
Thank you in advance!
Posted by floatingbridge on November 10, 2009, at 18:19:19
In reply to L-Dopa Dosing (what effects at what rate), posted by RMFlorida on November 10, 2009, at 8:38:27
Can't give you scientific info, just incidental. I have a relative w/ Parkenson's, and his meds have had to be adjusted once in the first year, which meant they were becoming less effective.
fb
Posted by floatingbridge on November 10, 2009, at 18:21:06
In reply to L-Dopa Dosing (what effects at what rate), posted by RMFlorida on November 10, 2009, at 8:38:27
Have you looked into miraprex? It really works for some (and doesn't for others). My doc has spoken of it as a possibility for me.
good luck,
fb
Posted by SLS on November 11, 2009, at 6:43:11
In reply to Re: L-Dopa Dosing (what effects at what rate) » RMFlorida, posted by floatingbridge on November 10, 2009, at 18:21:06
> Have you looked into miraprex? It really works for some (and doesn't for others). My doc has spoken of it as a possibility for me.
I wonder if adding Abilify or amisulpride would help stabilize dopaminergic synapses such that the Mirapex would not poop-out so readily. Low dose amisulpride might even prevent the sleep-attacks that are sometimes seen as a side effect of Mirapex.
Amisulpride might be worth combining with L-dopa to help facilitate an increase in synthesis and release of dopamine.
- Scott
Posted by sowhysosad on November 11, 2009, at 7:07:07
In reply to Re: L-Dopa Dosing (what effects at what rate) » RMFlorida, posted by floatingbridge on November 10, 2009, at 18:21:06
> Have you looked into miraprex? It really works for some (and doesn't for others). My doc has spoken of it as a possibility for me.
>
> good luck,
>
> fbMy neurologist also says he much prefers l-dopa to dopamine agonists because - at low-to-moderate doses and in the absence of Parkinson's - l-dopa has far fewer side effects.
Mild nausea is most common with l-dopa, compared to sleep attacks, hypersexuality etc that can be caused by dopamine agonists.
Posted by sowhysosad on November 11, 2009, at 7:07:46
In reply to Re: L-Dopa Dosing (what effects at what rate) » RMFlorida, posted by floatingbridge on November 10, 2009, at 18:19:19
> Can't give you scientific info, just incidental. I have a relative w/ Parkenson's, and his meds have had to be adjusted once in the first year, which meant they were becoming less effective.
>
> fbMy neuro says this is unique to people with Parkinson's.
He doesn't see this when he treats other neurological disorders - like dopa-responsive dystonia - with l-dopa.
The implication is that the declining response to levadopa may be caused by the degeneration of the dopaminergic system in Parkinson's, not by the levadopa itself.
Posted by floatingbridge on November 11, 2009, at 15:18:21
In reply to Re: L-Dopa Dosing (what effects at what rate), posted by sowhysosad on November 11, 2009, at 7:07:46
Oh, Thanks, Sowhysosad. Something I never understood. Thanks for clearing this up for me.
fb
Posted by RMFlorida on December 3, 2009, at 8:17:26
In reply to L-Dopa Dosing (what effects at what rate), posted by RMFlorida on November 10, 2009, at 8:38:27
Just wanted to "bump" the origina question:
I've noticed that the dosage in OTC L-DOPA nutrients varies significantly. For example, it's used in some 'brain supplement' mixes, as low as 1-2mg (standardized). However, there are supplements that contain as much as 100 - 250mg (standardized) per tablet.
Can anyone tell me at what level the average person might notice the effects of taking L-Dopa, and whether there is an issue with build-up/an amount I should not be taking daily?
This is the end of the thread.
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