Psycho-Babble Medication Thread 978085

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Seroquel XR and difficulty falling asleep

Posted by Sara Quill on January 27, 2011, at 15:26:54

I'm currently on 400mg of seroquel XR (along with lamictal, nardil, namenda, and klonopin), and overall I find it much better than the original, immediate release form, since I feel like there's a more even amount in my system, and I don't have to nap during the day.

However, I have to take it earlier at night (8pm as opposed to 9 or 10pm), since it takes longer for the concentration to reach a slight peak at night. Despite taking it earlier, I still don't get as tired at night as I did w/the immediate release, so I have difficulty winding down, my mind still active and racing, when at least the immediate release knocked me out at night.

Does anyone else have a problem with this? Have you found anything that helps, such as taking a low dose of the immediate release later at night, an hour or 2 after taking the extended release form?

Thanks!

 

Re: Seroquel XR and difficulty falling asleep

Posted by linkadge on January 27, 2011, at 17:50:58

In reply to Seroquel XR and difficulty falling asleep, posted by Sara Quill on January 27, 2011, at 15:26:54

Is is possible to take a combination of IR and XR?

Linkadge

 

Re: Seroquel XR and difficulty falling asleep

Posted by Sara Quill on January 27, 2011, at 18:22:24

In reply to Re: Seroquel XR and difficulty falling asleep, posted by linkadge on January 27, 2011, at 17:50:58

> Is is possible to take a combination of IR and XR?
>
> Linkadge

I think it's possible (depending on dosing of course) - although I'm not sure how much it will help - b/c once you get to a certain dose of seroquel, your histamine receptors eventually become saturated, so I'm not sure if additional seroquel will cause increased sedation. Although 400mg isn't the highest dose, so maybe there is "room" for additional sedation...

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