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Dr. Bob is Robert Hsiung, MD,
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Posted by undopaminergic on February 24, 2021, at 5:09:25
Here is a pretty extensive review of the pharmacology of serotonin 5-HT7 receptors:
https://sci-hub.se/https://doi.org/10.1021/acschemneuro.8b00283Lurasidone (Latuda) and vortioxetine (Brintellix, Trintellix) are antagonists at this receptor.
-undopaminergic
Posted by linkadge on February 24, 2021, at 18:40:04
In reply to Serotoning 5-HT7 receptors, posted by undopaminergic on February 24, 2021, at 5:09:25
Yeah, 5-ht7 antagonists supposedly have antidepressant properties (apparently through some circadian mechanism). I think LSD is a 5-ht7 agonist (as is oleamide). The herb black cohosh also interacts with this receptor (partial agonist)?
Linkadge
Posted by jay2112 on February 26, 2021, at 0:14:54
In reply to Re: Serotoning 5-HT7 receptors, posted by linkadge on February 24, 2021, at 18:40:04
I take a small dose of Latuda, 10mg,and it seems to help a bit with mood stabalization. Any higher dose gives me the hee-bee jee-bees...akathasia..inner restlessness.
Jay
This is the end of the thread.
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