![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by undopaminergic on September 28, 2021, at 14:23:48
I just finished reading this article, which is a good introductory review of nicotinic acetylcholine receptors and nicotine addiction:
https://sci-hub.se/https://doi.org/10.1016/j.neuropharm.2020.108256It claims nicotine has a half-life of 20 hours in humans. That doesn't sound right to me. Wikipedia reports a half-life of only 1-2 hours, although it mentions a metabolite, cotinine, with a half-life of 20 hours.
-undopaminergic
Posted by linkadge on September 28, 2021, at 16:07:23
In reply to Introduction to nicotinic receptors and nicotine, posted by undopaminergic on September 28, 2021, at 14:23:48
Interesting. Apparently cotinine is a serotonin reuptake inhibitor and has antidepressant properties.
Linkadge
Posted by undopaminergic on September 29, 2021, at 8:18:59
In reply to Re: Introduction to nicotinic receptors and nicotine, posted by linkadge on September 28, 2021, at 16:07:23
> Interesting. Apparently cotinine is a serotonin reuptake inhibitor and has antidepressant properties.
>
> LinkadgeFrom Wikipedia: "Similarly to nicotine, cotinine binds to, activates, and desensitizes neuronal nicotinic acetylcholine receptors, though at much lower potency in comparison. It has demonstrated nootropic and antipsychotic-like effects in animal models. Cotinine treatment has also been shown to reduce depression, anxiety, and fear-related behavior as well as memory impairment in animal models of depression, PTSD, and Alzheimer's disease."
https://en.wikipedia.org/wiki/Cotinine
-undopaminergic
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.