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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 2 to 26 of 26. Go back in thread:
Posted by Lamdage22 on March 6, 2022, at 2:06:03
In reply to Testosterone sollution complete/partial remission?, posted by Jay2112 on March 5, 2022, at 20:34:41
I have been saying this, no one believed me.
Posted by undopaminergic on March 6, 2022, at 8:06:20
In reply to Re: Testosterone sollution complete/partial remission?, posted by Lamdage22 on March 6, 2022, at 2:06:03
> I have been saying this, no one believed me.
What, exactly?
-undopaminergic
Posted by undopaminergic on March 6, 2022, at 8:06:37
In reply to Re: Testosterone sollution complete/partial remission?, posted by Lamdage22 on March 6, 2022, at 2:06:03
> I have been saying this, no one believed me.
What, exactly?
-undopaminergic
Posted by undopaminergic on March 6, 2022, at 8:10:13
In reply to Testosterone sollution complete/partial remission?, posted by Jay2112 on March 5, 2022, at 20:34:41
The possible HPA axis dysfunction was one of the reasons I started trimipramine. It reduces cortisol levels, and when it starts to wear off, the cortisol rises again. I take most of the dose at night, in an attempt to normalise the cortisol concentration curve.
-undopaminergic
Posted by Jay2112 on March 6, 2022, at 10:17:41
In reply to Re: Testosterone sollution complete/partial remission?, posted by undopaminergic on March 6, 2022, at 8:10:13
> The possible HPA axis dysfunction was one of the reasons I started trimipramine. It reduces cortisol levels, and when it starts to wear off, the cortisol rises again. I take most of the dose at night, in an attempt to normalise the cortisol concentration curve.
>
> -undopaminergic
>Hi UD:
Yes, I have tried trimipamine a few times, and seemed really good for sleep. Now, it has no AP qualities, correct? But it did feel a bit like say, a small dose of seroquel, Interesting....
Jay
Posted by Lamdage22 on March 6, 2022, at 10:55:22
In reply to Re: Testosterone sollution complete/partial remission?, posted by undopaminergic on March 6, 2022, at 8:06:20
> > I have been saying this, no one believed me.
>
> What, exactly?
>
> -undopaminergic
>I have been saying to get Testosteron checked, as a deficiency will cause psychiatric symptoms.
Posted by Lamdage22 on March 6, 2022, at 10:56:36
In reply to Re: Testosterone sollution complete/partial remission?, posted by Lamdage22 on March 6, 2022, at 10:55:22
What I found is that you shouldn't go low fat. It can cause low Testosterone. Mine is in the middle of the reference range now. I was eating low fat, mostly out of laziness. Now that I get adequate fat all is fine.
Posted by SLS on March 6, 2022, at 11:14:47
In reply to Re: Testosterone sollution complete/partial remission?, posted by Lamdage22 on March 6, 2022, at 10:56:36
Hi.
If there is any one hormone that should be checked, it would be thyroid.
In the 1980s, Cytomel (T3 / triiodothyronine) was frequently used as an augmenter in the treatment of depression.
For me, T3 made my depression (bipolar) MUCH worse
For me, T4 helped - just not enough.
- Scott
Posted by Phillipa on March 6, 2022, at 11:24:49
In reply to Re: Testosterone sollution complete/partial remission?, posted by SLS on March 6, 2022, at 11:14:47
Scott absolutely agree with you. Find a good endocrinologist. Don't try to treat alone. The message is to Jay. Phillipa
Posted by undopaminergic on March 6, 2022, at 11:31:42
In reply to Re: Testosterone sollution complete/partial remission? » undopaminergic, posted by Jay2112 on March 6, 2022, at 10:17:41
> > The possible HPA axis dysfunction was one of the reasons I started trimipramine. It reduces cortisol levels, and when it starts to wear off, the cortisol rises again. I take most of the dose at night, in an attempt to normalise the cortisol concentration curve.
> >
> > -undopaminergic
> >
>
> Hi UD:
>
> Yes, I have tried trimipamine a few times, and seemed really good for sleep. Now, it has no AP qualities, correct? But it did feel a bit like say, a small dose of seroquel, Interesting....
>
> JayTrimipramine has substantial antipsychotic properties. I recall reading about a German trial, where many psychotic patients could be discharged from hospital with trimipramine as their only antipsychotic.
-undopaminergic
Posted by Jay2112 on March 6, 2022, at 19:53:55
In reply to Re: Testosterone sollution complete/partial remission?, posted by Lamdage22 on March 6, 2022, at 10:56:36
> What I found is that you shouldn't go low fat. It can cause low Testosterone. Mine is in the middle of the reference range now. I was eating low fat, mostly out of laziness. Now that I get adequate fat all is fine.
Did you take supplemental T? Like androgel, shots, or the pill?
Thanks,
Jay
Posted by Jay2112 on March 6, 2022, at 20:02:00
In reply to Re: Testosterone sollution complete/partial remission?, posted by SLS on March 6, 2022, at 11:14:47
> Hi.
>
> If there is any one hormone that should be checked, it would be thyroid.
>
> In the 1980s, Cytomel (T3 / triiodothyronine) was frequently used as an augmenter in the treatment of depression.
>
> For me, T3 made my depression (bipolar) MUCH worse
>
> For me, T4 helped - just not enough.
>
>
> - ScottFunny, T3 did the exact same thing! I haven't really done much T4, but it was no where near as bad as cytomel! T3.
A few reasons I look at testosterone...one, being, is that women need a nudge of this stuff too, and it can really ummm..perk them up..lol. Just, not too much, of course.
But psych meds really suppress testosterone levels. Even in low-normal conditions, it can be devastating to overall physical and mental health.
Jay
Posted by Jay2112 on March 6, 2022, at 20:05:36
In reply to Re: Testosterone sollution complete/partial remission? » SLS, posted by Phillipa on March 6, 2022, at 11:24:49
> Scott absolutely agree with you. Find a good endocrinologist. Don't try to treat alone. The message is to Jay. Phillipa
Hi Phillipa. Yes, we are now in search of a good endocrinologist. I let the treatment, and the endo, go last time. I now realize this is a lifetime thing. Nice to hear from you Phillipa!
Jay :)
Posted by Jay2112 on March 6, 2022, at 20:07:45
In reply to Re: Testosterone sollution complete/partial remission? » Jay2112, posted by undopaminergic on March 6, 2022, at 11:31:42
> > > The possible HPA axis dysfunction was one of the reasons I started trimipramine. It reduces cortisol levels, and when it starts to wear off, the cortisol rises again. I take most of the dose at night, in an attempt to normalise the cortisol concentration curve.
> > >
> > > -undopaminergic
> > >
> >
> > Hi UD:
> >
> > Yes, I have tried trimipamine a few times, and seemed really good for sleep. Now, it has no AP qualities, correct? But it did feel a bit like say, a small dose of seroquel, Interesting....
> >
> > Jay
>
> Trimipramine has substantial antipsychotic properties. I recall reading about a German trial, where many psychotic patients could be discharged from hospital with trimipramine as their only antipsychotic.
>
> -undopaminergicI will keep that in mind, if/when I search for a new med. Thanks!
Jay
Posted by Phillipa on March 6, 2022, at 22:05:50
In reply to Re: Testosterone sollution complete/partial remission? » Phillipa, posted by Jay2112 on March 6, 2022, at 20:05:36
Jay it's been awhile. Hope life is treating you well. Phillipa
Posted by Phillipa on March 6, 2022, at 22:06:04
In reply to Re: Testosterone sollution complete/partial remission? » Phillipa, posted by Jay2112 on March 6, 2022, at 20:05:36
Jay it's been awhile. Hope life is treating you well. Phillipa
Posted by Lamdage22 on March 7, 2022, at 1:41:26
In reply to Re: Testosterone sollution complete/partial remission? » Lamdage22, posted by Jay2112 on March 6, 2022, at 19:53:55
> > What I found is that you shouldn't go low fat. It can cause low Testosterone. Mine is in the middle of the reference range now. I was eating low fat, mostly out of laziness. Now that I get adequate fat all is fine.
>
> Did you take supplemental T? Like androgel, shots, or the pill?
>
> Thanks,
> JayNo I didn't take anything. What I did is I lowered my Iodine and Selenium dose. I took too much and it slowed down my thyroid I think. And I increased my fat intake. Algae Oil, Hemp Oil, Olive oil, butter and whole milk. Low fat diet is a scam by the sugar lobby. The only thing you have to avoid is trans-fats.
Posted by Lamdage22 on March 7, 2022, at 1:43:11
In reply to Re: Testosterone sollution complete/partial remission?, posted by Lamdage22 on March 7, 2022, at 1:41:26
My T was on the low end and now it is in the middle of the reference range. If I can shed my overweight, which I try, it may go up more. And the Metformin I take doesn't help either. But I am going to keep it for now. I need it to help with sugar cravings.
Posted by SLS on March 7, 2022, at 6:22:20
In reply to Re: Testosterone sollution complete/partial remission? » Jay2112, posted by undopaminergic on March 6, 2022, at 11:31:42
Hi, UD.
> > > The possible HPA axis dysfunction was one of the reasons I started trimipramine. It reduces cortisol levels, and when it starts to wear off, the cortisol rises again. I take most of the dose at night, in an attempt to normalise the cortisol concentration curve.
That's a really interesting strategy. I didn't know that about trimipramine.
What's your best guess as to why trimipramine has value as an antidepressant? What mechanisms do you think might be involved?/
> Trimipramine has substantial antipsychotic properties. I recall reading about a German trial, where many psychotic patients could be discharged from hospital with trimipramine as their only antipsychotic.
I've been away too long. I never heard of that. That should be taught in every medical school.
- Scott
Posted by undopaminergic on March 7, 2022, at 16:31:20
In reply to Re: Testosterone sollution complete/partial remission? » undopaminergic, posted by SLS on March 7, 2022, at 6:22:20
> Hi, UD.
>Hi, SLS.
> > > > The possible HPA axis dysfunction was one of the reasons I started trimipramine. It reduces cortisol levels, and when it starts to wear off, the cortisol rises again. I take most of the dose at night, in an attempt to normalise the cortisol concentration curve.
>
> That's a really interesting strategy. I didn't know that about trimipramine.
>
> What's your best guess as to why trimipramine has value as an antidepressant? What mechanisms do you think might be involved?/
>The histamine H1-receptor antagonism is of course somewhat useful for sleep. The serotonin 5-HT2A-receptor antagonism may somewhat increase dopamine release in the prefrontal cortex. However, a particularly unusual effect of trimipramine, and apparently unique in an antidepressant, is the histamine H2-receptor antagonism. Famotidine, a selective H2-antagonist, has shown promise in the treatment of the negative (aka. deficit) symptoms of schizophrenia:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1188579/
which is relevant because these symptoms overlap a great deal with depression.I have unsuccessfully tried to elicit feedback (any comment) here on the histamine H2-antagonism. So, I have to say it is only my hunch that this effect is highly significant in the antidepressant mechanism of action of trimipramine.
-undopaminergic
Posted by Jay2112 on March 8, 2022, at 13:58:48
In reply to Re: Testosterone sollution complete/partial remission? » SLS, posted by undopaminergic on March 7, 2022, at 16:31:20
> I have unsuccessfully tried to elicit feedback (any comment) here on the histamine H2-antagonism. So, I have to say it is only my hunch that this effect is highly significant in the antidepressant mechanism of action of trimipramine.
>
> -undopaminergic
>One antihistamine I have used for dizziness, betahistine, works on the H3 receptor, as an antagonist, and an H1 agonist. It apparently has weak affinity for H2 as a partial antagonist.
Jay
Posted by Lamdage22 on March 9, 2022, at 3:06:04
In reply to Re: Testosterone sollution complete/partial remission? » undopaminergic, posted by Jay2112 on March 8, 2022, at 13:58:48
Did it shut down your own production? You say you took it and then paused. What was your free T value, if you don't mind? And what is it now with TRT?
Posted by Jay2112 on March 13, 2022, at 14:20:26
In reply to Re: Testosterone sollution complete/partial remission?, posted by Lamdage22 on March 9, 2022, at 3:06:04
> Did it shut down your own production? You say you took it and then paused. What was your free T value, if you don't mind? And what is it now with TRT?
Sorry for the lag in response...I just found your post up here now.
When I first took T (14 or so years ago)..it was a bit bizarre. It took about 2 or so months to get the 'sex' effect, but after a month I was feeling pretty good. The first month, it over-flowed my total T (as it first mixes in with your own....but after it shuts down/replaces it).
Are you on T replacement?
Jay
Posted by Lamdage22 on March 13, 2022, at 21:31:55
In reply to Re: Testosterone sollution complete/partial remission? » Lamdage22, posted by Jay2112 on March 13, 2022, at 14:20:26
I was considering it, however with some changes, my T has gone to the middle of the reference range. I was taking too much Iodine and Selenium which slowed my thyroid, ontop of that I wasn't consuming enough fat calories. The body needs fat to build Testostoerone. Fixing these fixed my T level.
Posted by Lamdage22 on March 15, 2022, at 1:51:14
In reply to Re: Testosterone sollution complete/partial remission?, posted by Lamdage22 on March 13, 2022, at 21:31:55
It also could be a lower stress level due to advancements in therapy. Who knows. But the problem is fixed for now.
This is the end of the thread.
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