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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by rjlockhart37 on April 18, 2022, at 13:26:02
nuerotin has not been helping but ill post years ago, i was on a little high dose, 3200mg (4 800mg tablets daily) and i rerember at those doses it had a antidepressant, i rerember it would have a safetly net effect, felt stable and in content mood. I was on lyrica for about 3 months, and we stopped it because switched over to another med. Gabapentin does have some postive effects on mood, i've noticed, it's less potent than lyrica - i've read people have very good mood enhancements on it. Right now im on 600mg X 3 daily. I'm eventually going to go off it, it's effects at those doses do not work so much, it has a tiny antianxiety effect but not enough to treat it.
Anyways, gabapentin at higher doses has postive effects on mood, not sure the mechanism of action, it has enhancements on gaba, but does not effect or work on gaba receptors. It's very common med for nerve pain. That's ill say....it has small abuse potential but nothing that would consider it a controlled substance
Posted by rjlockhart37 on April 18, 2022, at 13:30:19
In reply to nuerontin's antidepressant effects, posted by rjlockhart37 on April 18, 2022, at 13:26:02
i did want to post it does have positive effects on mood, the dosage could very on the person, some people get antidepressant effects at even low doses, i've gotten tolerant to it, it has a tiny effect, nothing to treat my anxiety levels. It could be a good choice in some people treating bipolar disorder when taken with lamotagine and other mood stablizers
Posted by Christ_empowered on April 18, 2022, at 17:04:08
In reply to Re: nuerontin's antidepressant effects, posted by rjlockhart37 on April 18, 2022, at 13:30:19
i often wonder how many psych problems could be (and are, probably) improved if someone would just developer safer, easy to tolerate sedatives.
in some old drug ads..."whatever the diagnosis, LIBRIUM." because...yeah...everyone, from moody teenagers to angry manic depressives, could use a Librium. I...agree with that, actually. :-)
apparently, just about any substance that reduces anxiety and tension can result in "improvement" on various depression scales. That's part of why Seroquel can "improve depression" in some small studies even with incredibly low doses (read: more antihistamine than cns drug at those doses...).
benzodiazepines, too, can help. and neurontin, for some (many?) people. and...
Ever taken ashwagandha? I do, now...Jarrow brand, so far so good. Its been tested at higher doses for adjunctive use in stable, medicated people with long term Schizophrenia who are showing signs of relapse (I think back in the day they would call that "acute exacerbation of Schizophrenia" and/or "the prodromal phase" or...something, I dunno...). kind of...a very select patient group, I think, but...
yeah, it helps. or it seems to, in that small study. and its non-toxic, I don't think there's a discontinuation syndrome, and..yeah. yeah. I think it may have some antioxidant effects, so one could argue for it being relatively inexpensive, readily available, safe, and potentially beneficial in some respects, on top of the psych stuff.
so, yeah. in that small study, a lot of the stable (but approaching..instability?!?) people were able to keep on keepin' on and improve -negative symptoms- (I find that interesting...to me, those overlap with depression, and neuroleptics seem to exacerbate them, in a lot of people...), and the neuroleptic dosage stayed steady, which is an excellent thing for long-term health and such.
ok. I don't care much for gabapentin, personally. I seem to somehow...get more -obvious- cognitive impairment than I was expecting, and my mood is sometimes brighter, but less...even. not that I go crazy, just...ugh. -next Rx, please...- it happens.
thanks for the post. :-)
Posted by undopaminergic on April 19, 2022, at 17:26:19
In reply to Re: nuerontin's antidepressant effects, posted by Christ_empowered on April 18, 2022, at 17:04:08
> apparently, just about any substance that reduces anxiety and tension can result in "improvement" on various depression scales. That's part of why Seroquel can "improve depression" in some small studies even with incredibly low doses (read: more antihistamine than cns drug at those doses...).
>There are central (CNS) histamine receptors.
-undopaminergic
This is the end of the thread.
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