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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by jerimycoplo on December 23, 2003, at 7:33:13
I'm interested to see if anyone has any feedback on this. I was thinking about what sort of medications would when combined create an acute (short term) effect similar to that off alcohol intoxication. Now i've researched and so far I know that alcohol roughly following effects on neurotrnasmiters:
GABA increase - thus disinhibition
dopamine,seratonin increase
glutamate inhibition (since it's excitatory neurotransmitter, this means more cns depression)
and some minor opiate neurotrasnmitter effects.
Any combination is obciously not going to be just like drinking but, nevertheless i'm trying to figure out a roughly close one that one that would result in disinhibition and some energy though and wellbeing like when u drink
I figure a benzo like (xanax) would be perfect for starting off (anti anxiety and short term fast acting). Do any of you have any suggestions on what else could be added to cause a quick increase in dopamine, norephinephrinee or anything else, that would mainly counteract the sedating effects of the benzo alone?( the benzo alone works for anxiety but at same time causes more sedation i think then alcohol) Or any other suggestions on what might work in combination? thanx
Posted by justyourlaugh on December 23, 2003, at 13:37:46
In reply to alcohol resembling drug combos, posted by jerimycoplo on December 23, 2003, at 7:33:13
Posted by jerimycoplo on December 27, 2003, at 14:04:15
In reply to gabapentin??? (nm) » jerimycoplo, posted by justyourlaugh on December 23, 2003, at 13:37:46
Hey I was wondering whether anyone had any feedback about the use of dopamine reuptake inhibitors (Mirapex? etc.) for depression and anxiety. I have ocd and ssri's do fine for that, but there's also some sort of anxiety disorder (social phobia i believe). It is hard to explain, but in a nutshell i constantly feel like i'm being scrutinized by others, persecuted, feel constantly inferior to my peers even when i don't even know them). For example i can feel inferior to people just goignt o the mall just because i see other people my age. This causes me anxiety, which in turn makes my social life non existant or strange and aquard. I also have horifically low self esteem (as a result of my disorder? or as a cause of it?). In any case, i was diagnosed with ocd, depression and anxiety disorder. The ssri's i've tried mainly and they help with the ocd but not with the anxiety and social issues at all. Furthermore they help with depression but my depression comes back, because it is caused by my lack of social adjustment. So my social anxiety) or whatever it is makes me depressed cuz i have trouble forming normal relationships with people and therefore having a normal life and i obviously regret that and feel hopeless about my future prospects of ever being "normal".
Alcohol does wonders for me (i rebound socialize when drinking to a insane degree and feel like the world is amazing), but that's not a long term solution. In time i have found that lifting weights seems to help more with my social issues then any meds combined i've evee taken. Therefore I am an avid weightlifter (since i see it as the only way to feel more "normal" about my place ...socially).
I have tried all the ssri's, remeron, neurontin. They do nothing for my social issues. A minimal dose of any ssri will correct my ocd (which was mainly obssesive fears of dying and aging). I really wish i could find some meds that would help me with the anxiety. I was wondering whether any improvement might occur with attacking my disorder using a "dopamine" side medication. (like mirapex, maybe wellbutrin) etc.? the ssri's dont' seem to do anything except my ocd in check. any other ideas, comments or personal experiences would be welcome.
thanx
jc
Posted by krazybirdlady on December 28, 2003, at 16:34:43
In reply to DRI? for depression and anxiety help!, posted by jerimycoplo on December 27, 2003, at 14:04:15
i identify with you completely. might i be so bold as to ask for all the meds you are currently taking? beating the OCD is a major feat. the SAD is another story. it might take hit or miss for awhile, as well as some therapy. and in my opinion, you never really overcome it. you just learn new and better ways to mask it. i know from personal experience that alcohol is not the answer. you obviously know that too. Paxil worked for my SAD, but not without its downfalls. my heart goes out to you, as i know what kind of road this is..
Posted by JonW on January 6, 2004, at 20:11:24
In reply to alcohol resembling drug combos, posted by jerimycoplo on December 23, 2003, at 7:33:13
> I'm interested to see if anyone has any feedback on this. I was thinking about what sort of medications would when combined create an acute (short term) effect similar to that off alcohol intoxication.
If I understand you correctly, you are saying that your choice in self-medication (alcohol) is an indicator of what drugs might be helpful for you. Logical, but be careful not to just substitute one addiction for another. You could try the herb Kava. It's effects are very similar to alcohol, but slightly more mellowing. Be careful with it, though. For me, 2 strong Kava drinks = six beers. When I say Kava, I mean the good stuff from hawaii (like http://www.konakavafarm.com). Kava is absolutely disgusting, and you may want to encapsulate the powder and swallow pills instead. I don't know if that would change the potency of its effects or not as I've only prepared it the traditional way. Anyway, Kava is what came to mind when thinking of something similar to alcohol.
This is the end of the thread.
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