Posted by Adam on May 3, 2000, at 10:39:22
In reply to Re: Parnate+Another Opinion, posted by Ant-Rock on May 3, 2000, at 7:36:37
Ant,
Wow, that's news to me. I have, in the past, wondered about low-dose selegiline/tranylcypromine combinations, but 30mg is hardly a low dose of selegiline. Do you have the name of this doctor? I'm very curious to read about his methods, if there is anything to read.
At any rate, serious adverse reactions to MAOI combinations are, as they say, rare. However, if my memory serves me, when there is an adverse reaction, it can be anywhere from unpleasant to fatal.
I'm also suprised at the idea of a selegiline/tranylcypromine combo at non-specific doses for simple conceptual reasons, and wonder what the rationale is.
I still think Judy's experiences are unlikely to be related to a therapeutic combination of selegiline and Parnate. Again, as I said, if she waited two weeks after stopping selegiline to start Parnate, there should have been essentially no selegiline in her system, and MAO levels should have been approaching normal.
Judy, just as an aside, I don't want to, with my discussion of lithium and its effects on the GABA system, minimize the primary rationale for lithium augmentation of antidepressants, which is the potentiation of serotonergic neurotransmission (though, for instance, the effects of lithium on second messenger systems involved in some serotonin signalling puts an interesting spin on this). The Parnate lithium combo. seems to be especially common, though lithium and Nardil are certainly also used successfully, and this is presumed to be a serotonin-related effect. What I find intriguing about the lithium/Parnate combo. is that, while lithium seems to mediate positive GABAergic effects, GABAergic effects can be antagonized by dopamine, and of particular interest is the dopamine D2 receptor in this feedback system. It is worth noting that Parnate is thought to have strong effects on D2. These two drugs have an intriguing pas de deux.
> Hi Judy,
> I do know of a doctor in the Georgia area who treats many refractory patients successfully with the parnate/deprenyl combo. A woman I corresponded with did very well on 40mg Parnate, 30mg Deprenyl. I believe there was even a study being done using these meds, but this was going back a few years. The Dr. I spoke of is part of a research oriented program who treats many patients with new and non-traditional protocals.
> Please do not discount the info in Adams post, as he is certainly more knowledgable regarding meds than myself.
> I just thought I'd let you (or anyone) know that this combo is, though probably rarely, being used.
> One question Judy,I think you mentioned Nardil being better for your anhedonia than Parnate. Could you please elaborate on the benefits of nardil vs parnate that you experienced. I had a good energizing effect from parnate, but it didn't improve my anhedonia, which has really been a problem for me. Maybe nardil would work better? I didn't realize these two drugs could have different AD properties.
> Thanks Judy,
>
> Anthony
poster:Adam
thread:31946
URL: http://www.dr-bob.org/babble/20000429/msgs/32040.html