Posted by JohnL on June 15, 2000, at 3:39:12
In reply to Parnate and Adrafanil?, posted by Ant-Rock on June 14, 2000, at 13:59:54
> Does anyone know if these two meds can be combined?
> My current ritalin/amisulpride augmentation isn't cutting it and I would like to try a different augmentor before once again increasing the parnate. I just recieved my adrafanil so I could start right away.
> Also, my IAS(int.anti-aging system) price list has a new anti-depressant listed called Nivalin(Galantamine),says it's a "reversible acetylcholine transferase inhibitor". Anyone ever try this med. How does it work? what does it do?
> Sincerely,
> AnthonyAnthony,
I don't know anything about Nivalin.But I am familiar with Adrafinil and I don't see any reason you couldn't combine it with Parnate. My primary concern would be the combined effect of hyperadrenergic effects, which would likely manifest itself in feelings of agitation or irritation or worsened depression.
Since neither Ritalin or Amisulpride are cutting it, that kind of hints that dopamine is not a chemistry you respond to. So that makes the case for Adrafinil more convincing, since it acts on the NE system rather than the dopamine system. Also worth considering is that neurotransmitter levels with you could likely be OK, and down-regulation by increasing those levels not necessary. If your levels were low, or down regulation needed, then I would think you would have had a more positive reaction to Parnate alone. It's just a guess, and you know better than me, but the whole Parnate thing might be off target.
Personally I found Adrafinil to be the kindest gentlest and yet most effective of all the stimulants. But that's just me.
In your shoes I would start by cutting a 300mg pill into halves and start with 150mg a day for a week just to feel it out and test the waters before jumping in. But again, that's just me. I tend to be cautious, and I believe in low and slow, especially when dealing with medications our personal physicians are not real familiar with. If after a week all is well, then higher doses could be tried.
In one source I noticed Adrafinil's usual dose is 600mg to 1200mg. In another it is 300mg to 600mg. Personally I found 300mg perfect, after trying all different doses.
JohnL
poster:JohnL
thread:37287
URL: http://www.dr-bob.org/babble/20000610/msgs/37347.html