Posted by Sunnely on February 27, 2001, at 23:17:38
In reply to Re: Electric Shock » Sunnely, posted by Cam W. on February 27, 2001, at 6:47:27
Sorry, other than the hypothesized hyposerotonergic state causing SRI-withdrawal symptoms, not sure if there are other mechanisms involved. However, I think you may be right about the problem with reupregulating the norepinephrine (NE) having a role in withdrawal symptoms.
When we think of SRI-withdrawal, we seem to think immediately of the role of serotonin (5HT), and tend to forget that 5HT, NE, DA, acetylcholine (muscarinic), GABA, etc. are extensively colocalized in the brain that one neurotransmitter tends to interfere/influence another neurotransmitters's function. For example, paroxetine (Paxil), although an SSRI has also anticholinergic effect (in higher doses). Abrupt discontinuation may bring about symptoms of hyposerotonergic state and "cholinergic rebound." With regard to Effexor, abrupt discontinuation may lead to symptoms of hyposerotonergic and NE-deficiency states.
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> Sunnely - I have heard of this "electric shock" in the head. It seems to be a long-term symptom of seroternic drug withdrawl and can last months. It has been described as a "kind of vibration/crackling or short-lived pop/buzz" in the head. This is one side effect that has made me wonder on several occasions. It does seem to start upon abrupt withdrawl of the short acting serotonergic agents and can even continue when a weaning regimen is reinstated. I have never personally heard of someone mention this, but have read of it in the literature. I do not know what kind of weaning process was eventually initiated,
> either. It seems to be a real phenomenon, though, and could have to do with either a problem of reinstating appropriate levels of the serotonin reuptake transporter, the 5-HTB1 receptor, or the norepinephrine reuptake transporter; all of which have recently been shown to be linked to one another. I have a feeling (and it is just a feeling) that the inability of certain people's biochemistry to "renormalize' or upregulate the norepinephrine transporter upon withdrawl of the serotonergic agent may be at the heart of these "electric shocks".
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> Do you have any comments or thoughts on this? - Cam
poster:Sunnely
thread:54758
URL: http://www.dr-bob.org/babble/20010221/msgs/55056.html