Posted by SLS on April 23, 2001, at 18:26:18
In reply to Re: Geodon and nausea, anyone?, posted by Sunnely on April 22, 2001, at 22:35:17
Dear Sunnely,
> Again, above opinion is just a "hunch" and needs to be supported by scientific study.
>
> References:
>
> 1. Package Insert, Geodon (ziprasidone HCl), Pfizer, February 2001.
>
> 2. Essential Psychopharmacology, 2000, second ed., Stephen M. Stahl, Cambridge University Press, Cambridge, UK.
>
> ++++++++++++++++++++++++++++++++++
I apologize for the misunderstanding. My wording of the question pretty much sucked.I was not asking you about your hunch. Based upon the supposition that ziprasidone inhibits the reuptake of norepinephrine and serotonin, it seems very reasonable.
> I am sure you know that Geodon is both a reuptake inhibitor of serotonin and norepinephrine.
That's just the thing. I'm not. I am not contending otherwise, but I want to see the data resulting from experiments, not just a repetitive pronouncement of the acceptance of these properties as being putative. It might be important information to be considered when making a decision to combine ziprasidone with an MAO inhibitor.
I would like to see any references that may be cited in the package insert. I believe that I have come across instances in the past where a single physiological study has served as the basis for subsequent statements and considerations. I would like to know that there are some experiments that demonstrate and corroborate the contention that ziprasidone is a reuptake inhibitor other than this one study that I found cited in a piece I found on the Internet:
Seeger TF, et al. Ziprasidone (CP-88,059): A new antipsychotic with combined dopamine and serotonin receptor antagonist activity. J Pharmacol Exp Ther 1995;275:101-113.
Since I read in another piece that alluded to previous work demonstrating reuptake inhibition using 'in vitro' synaptosomal preparations, I am guessing that they were referring to the Seeger study. I couldn't find the abstract on Medline.
What is the source of Dr. Stahl's information?
Now, having said and asked all of that, I want to thank you very much for supplying the information and your perspective to Anita. Your post provided her with true guidence and support, something I was then incapable of. You have also helped me because I might try ziprasidone in the near future.
Thanks again.
Sincerely,
Scott
poster:SLS
thread:60754
URL: http://www.dr-bob.org/babble/20010417/msgs/60895.html