Posted by Mitch on June 3, 2001, at 12:07:00
In reply to Re: Studies: New Celexa promising, posted by SLS on June 2, 2001, at 22:53:59
> Mitch - can you recall about when the article regarding nortriptyline was published?
SLS, It is quite old, but here is the entire
abstract,Mitch
Neuropsychobiology 1996;34(1):44-8
Antidepressant and anxiolytic profiles of E-10-hydroxynortriptyline on electrocorticograms of rats.
Nordin C, Krijzer F.
Department of Clinical Neuroscience and Family Medicine, Karolinska Institute, Huddinge University Hospital, Sweden.
Electrocorticograms of rats were recorded after administration of increasing doses of the major metabolite of nortriptyline (NT), E-10-hydroxynortriptyline (E-10-OH-NT). The results were compared with those of NT administration. In visual as well as computerized evaluations, E-10-OH-NT demonstrated clear antidepressant properties, thus confirming previous experiments in depressed patients. There is some evidence that E-10-OH-NT also has an anxiolytic profile. The results with the parent drug NT were not so pronounced. Since E-10-OH-NT has been shown to be devoid of side effects when previously administered to humans, this substance is clearly to be considered of interest for potential development into a new antidepressant. Whether or not the anxiolytic profile is of clinical interest needs to be investigated further.
PMID: 8884759 [PubMed - indexed for MEDLINE]
poster:Mitch
thread:64685
URL: http://www.dr-bob.org/babble/20010530/msgs/65245.html