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Re: Remeron question for Sal et al » Amy Blue

Posted by SalArmy4me on June 30, 2001, at 2:24:18

In reply to Remeron question for Sal et al, posted by Amy Blue on June 29, 2001, at 22:10:57

Radhakishun, Fenny S. PhD. Mirtazapine Effects on Alertness and Sleep in Patients as Recorded by Interactive Telecommunication During Treatment With Different Dosing Regimens. Journal of Clinical Psychopharmacology. 20(5) Oct 2000:

"Patients receiving the fixed dose {of mirtazapine} reported earlier sleep onset and longer duration. Similar mean changes in HAM-D scores (approximately -40%) and frequencies of CGI responders ( >50%) occurred in both groups. The regimens were equally well tolerated. Somnolence, the most frequent side effect, was reported by only 10% of each group during the first week and by fewer patients during the second. Mirtazapine in fixed and ascending nocturnal dosing regimens was found to facilitate sleep, but it does not generally reduce daytime alertness. The fixed regimen seems preferable because of its greater effects on sleep..."


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