Posted by Elizabeth on July 19, 2001, at 7:50:28
In reply to Imipramine vs Desipramine : Experiences, opinions?, posted by thrasher on July 18, 2001, at 8:07:48
> Imipramine
> *Tends to sedate (excellent sleepy feeling within 45 mins)Desipramine can make some people jittery. (So can imipramine, for that matter, but I think desipramine might do this to some people who find imipramine sedating.) As far as I can tell, it's not sedating at all.
> *Tends to be anticholinergic (gulf mouth syndrome)
Also: constipation, increased heart rate, cognitive impairment, ...
Desipramine is relatively lacking in anticholinergic side effects.
Imipramine is probably better for panic disorder.
> *Upsets those with ulcers or reflux
That might be related to serotonin; desipramihne is a relatively selective norepinephrine reuptake inhibitor.
> In contrast to this, what does desipramine do? I have not tried it, and cannot find goodre
> reference to the difference in literature.That's surprising. It's very commonly used because it tends to be more tolerable than most of the other tricyclics. I've been taking it for about 2 1/2 weeks and am beginning to notice some improvement, without any side effects (except maybe a little dry mouth, but that could just be from another medication that I'm taking). I'm not finding it helpful with concentration and focus (attention problems), though.
-elizabeth
poster:Elizabeth
thread:70607
URL: http://www.dr-bob.org/babble/20010714/msgs/70819.html