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Re: Do Tricyclic side effects wear off? » Elizabeth

Posted by MB on September 12, 2001, at 1:40:15

In reply to Re: Do Tricyclic side effects wear off? » stjames, posted by Elizabeth on September 11, 2001, at 14:56:58

Can you tolorate H-1 blockade pretty well in general? For me, anything that blocks H-1 knocks me on my butt (and that goes equally for the drugs that "don't cross the blood-brain barrier" like Zyrtec). Is it just your body's response to H-1 blockade? My dad, for example, can take Benadryl and go about his day like it was nothing but a sugar pill. Or, is there something unique about the tricyclics that make you impervious to the sedation?

> FWIW, desipramine doesn't seem to cause any sedation at all, and it was only mild with the other two TCAs I've tried (nortriptyline and amoxapine).
>
> -e


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