Posted by dennison on September 21, 2001, at 14:23:30
In reply to Re: Restless legs and Effexor » Fred Potter, posted by SalArmy4me on September 21, 2001, at 2:52:56
> I found that a little bit of trazodone at night gets rid of the restless legs.
HiFred--that would certainlybe my interpretation--restlessness of muscles from dopamine diminution from serotonin overdrive. Serotonin "disinhibits muscle fibers" which causes the twitching which is first level of disinhibtion --- spasms and myoclonus "alternating contraction and relaxation of muscles" --2nd level and muscular stiffness especially in neck is jsy a reflection of the constant muscular tension!!! Even though serotonin doesn't block dopamine receptors like anti-psychotics any time serotonin function is enhanced dopamine function is reciporacally diminished. That's why wellbutrin with it's effects on dopamine is so common used in conjunction with ssri's--to offset this lowering dopamine efficiacy from serotonin enhanced function!!!
poster:dennison
thread:79186
URL: http://www.dr-bob.org/babble/20010917/msgs/79231.html