Posted by Hattree on October 19, 2001, at 21:56:11
In reply to Proposed Mechanisms of Action of Lamotrigine, posted by Cam W. on October 19, 2001, at 19:08:33
> It has been also noted that Lamictal also weakly blocks the serotonin reuptake mechanism (like the SSRIs) and may have anti-kindling action (like valproate and carbamazepine).
>
> I hope that this explains some of the actions of Lamictal. This drug basically slows overactive nerves, and allows antidepressants to help to recouple the body's stress defense, the HPA axis. Since Lamictal only calms neurons and doesn't "fix" the HPA axis, it would not make a good antidepressant by itself, but it does help antidepressants work better by calming down overactive neurons. This should also possibly explain why Lamictal augments other mood stabilizers in bipolar depression, as well.
>
I have good luck w/Lamictal and Zoloft, but would rather take Serzone because I experienced fewer side effects. Would this combo be likely to work?
poster:Hattree
thread:81710
URL: http://www.dr-bob.org/babble/20011015/msgs/81718.html