Posted by dazednconfused on February 18, 2002, at 7:17:10
In reply to Re: DA downregulation Postsynaptic Hypothesis. » dazednconfused, posted by JohnX2 on February 16, 2002, at 11:52:33
Hi John,
your theory is quite interesting!
If i had understand well you mean that:
more dopamine in the synaptic zone=more post-syn aptic receptors;
more post-synaptic receptors=more pre-synaptic receptors;
more pre-synaptic receptors=more reuptake of dopamine in the intercell zone;
more reuptake of dopamine=less dopamine available in your brain.
The circle is closed and it seems don't to have an end!
I could be agree with you, but let me suppose that we could break this circle:
we know that 100 mg of amisulpride, L-sulpiride or 400 mg of sulpiride, totally saturate the pre-synaptic receptor, making them completely off.
So we could stop the reuptake of dopamine at all!
However, if it shouldn't works, we could anyway increase the amount of dopaminergic med till we could block all pre-synaptic recetors.
You know you could increase amisulpride up to 400 mg or more without interact with post-synaptic cell, and so, acting only at pre-synaptic receptors level.
What's your opinion about? What could you suppose to do in this case?
Bye
poster:dazednconfused
thread:94402
URL: http://www.dr-bob.org/babble/20020215/msgs/94485.html