Posted by SLS on November 28, 2002, at 1:12:48
In reply to Re: So you think Parnate is as good as Nardil?, posted by djmmm on November 27, 2002, at 7:33:27
Hi.
Parnate can very definitely be effective for social phobia. I haven't looked for anything comparing Parnate to Nardil with regard to SP, but I still get the feeling that Nardil would help more people. Although it might not be important, Nardil causes the levels of GABA to increase by inhibiting GABA-transaminase (an enzyme used by the body to help break-down excess GABA). If this is indeed important, perhaps finding a GABAergic drug to add to Parnate would increase one's chances of responding.
- Neurontin (gabapentin)
- increase GABA synthesis
- Gabitril (tiagabine)
- GABA reuptake inhibitor
- Sabril (vigabatrin)
-GABA-transaminase inhibitor
- Depakote (valproate)
- increases GABA turnover
- increased GABA synthesis (glutamic acid decarboxylase)
- decrease GABA break-down (GABA-transaminase)Note: Like Nardil, Sabril inhibits the GABA-transaminase enzyme. Perhaps adding Sabril to Parnate would yield a positive result.
Just taking a few stabs at it...
- Scott
poster:SLS
thread:129025
URL: http://www.dr-bob.org/babble/20021127/msgs/129681.html