Posted by jasmineneroli on January 12, 2005, at 0:28:43
In reply to Re: Klonopin/Depression,why?, posted by Mr.Scott on January 12, 2005, at 0:06:53
This is really interesting.
I did know that clonazepam has a very slight serotonergic effect. That's why I think it helps those of us with Generalized Anxiety Disorder. Perhaps when it's combined with an AD, it makes depression worse??
Slow metabolization of this drug in the liver, may well cause "toxic" effects, since the drug is around much longer and as you keep adding a dose it just builds up. I have this problem with drugs that require liver CYTP450 enzyme 2C19 (Celexa & Moclobemeide to name 2). I get really bad side effects from them and needed a very low dose to be therapeutic, in the end they made me depressed!!!
Perhaps something similar is going on with Clonazepam for some of you guys??I love clonazepam myself, but if you plot your reactions and feel it's making you worse, maybe it's time to change, just as you would for any other drug.
Wishing you guys luck!
Jas
poster:jasmineneroli
thread:438523
URL: http://www.dr-bob.org/babble/20050108/msgs/440959.html