Posted by bleauberry on December 29, 2018, at 8:20:39
In reply to Anyone ever augment a TCA with Zoloft or Remeron?, posted by Schlepo on December 24, 2018, at 10:02:23
I've been on every combination you can think of involving these 3 meds.
I do not think you can predict the results in advance with these. You just have to try and see what happens.
Combining any of them does make sense because their respective mechanisms are very different. The anti-histamine effect would be extra strong with Nortriptyline and Remeron together but that is not necessarily a bad thing, and potentially therapeutic (in my thinking, many depressions have inflammation at their root and that means excess histamine response).
For me any of these alone were too emotionally numbing, and any combinations of them were even more numbing.
If you need some sort of arousal or pleasure component in your antidepressant therapy then you need to be looking at the stimulants not the reuptake inhibitors.
> I've seen these combos suggested for augmenting nortriptyline, and wondering if anyone ever actually tried them. There are some theoretical contraindication concerns with Remeron, but I've heard its possible to combine them since they don't act on the exact same areas. Any clarifications for either combo?
poster:bleauberry
thread:1102596
URL: http://www.dr-bob.org/babble/20181024/msgs/1102638.html