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Re: Pindolol (a beta-blocker) can alleviate depression » phidippus

Posted by Hugh on December 11, 2019, at 19:36:27

In reply to Re: Pindolol (a beta-blocker) can alleviate depression » Hugh, posted by phidippus on December 11, 2019, at 18:53:22

Since you have bipolar 1, I thought you might find this pindolol study interesting:

At the end of the acute treatment (day 10; i.e., four days after the last TSD cycle) 75% of bipolar depressed patients treated with coadministration of pindolol and TSD (versus 15% of patients treated with placebo and TSD) showed a complete response. One week after 70% and 5% of patients respectively were still rated as responders.

These data confirming the presence of a positive interaction between pindolol and TSD are in agreement with the hypothesis of a major role of 5-HT neurotransmission in the mechanism of action of TSD.

Complete article:

https://www.nature.com/articles/1395312


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