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Re: Anxiolysis does not need to be addictive

Posted by undopaminergic on October 11, 2020, at 1:29:38

In reply to Re: Anxiolysis does not need to be addictive » undopaminergic, posted by linkadge on October 10, 2020, at 15:24:12

> >Even if this were true, I don't see how it makes >a difference, from the point of view of my >desiring to continue either treatment.
>
> Yes, I would agree with that, so long as both can work in the long term. Studies on the ability of ritalin to improve depression in the long term are lacking. Most traditional antidepressants don't directly activate the reward system. They can (over time) improve the functionality of the reward system, but they probably do this through complex mechanisms. Over time, most traditional antidepressants reduce brain inflammation, reduce microglial activation, normalize the HPA axis, improve neurogenesis etc. Ritalin shares none of these properties. So, yes, at the end of the day if it 'works' it doesn't really matter. The caveat is whether ritalin can work long term, and whether (over time) it improves the course of illness or worsens it.
>
> Linkadge
>

One difference is how fast they act. (M)ethylphenidate works within minutes, and trimipramine takes days and weeks. The stimulant can have withdrawal effects (lethargy) or it can have some positive after-effects (feeling better for some days), but generally it is effective only for the duration of its direct actions. Relapse often (if not usually) happens with antidepressants too, but it takes longer.

-undopaminergic


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URL: http://www.dr-bob.org/babble/20200711/msgs/1112261.html