Posted by sdb on July 28, 2007, at 16:51:46
In reply to Re: Xolair - New Anti IgE Treatment }} Lonely » sdb, posted by Lonely on July 28, 2007, at 14:58:46
> Wow! It's great to have this information and thank you for posting.
>
> On the report it says: "Findings: The heart size is enlarged. There is left atrial enlargement with calcification of the mitral valve. The main pulmonary artery diameter measures 25 mm. The right pulmonary artery diameter measures 19 mm and the left pulmonary artery diameter measures 22 mm." The test was done without contrast and it goes on to describe the lungs.
>
> So, I have no idea if the enlargement was just referring to the left atrial or the whole heart. Is there any way to tell?
>
> If you wouldn't mind, could you explain about the aminoacid structure and glycolisation and the inconsistency it would have on cells nearby? Does this mean that the ultimate effect could be like many meds, that is, cause effects not really intended - i.e., commonly referred to as side effects?
>
> My hubby is on another monoclonal antibody - it's approved by the FDA for limited use in a few centers across the country for MS. Xolair was approved about 3 years ago although many doctors don't seem to really know what I'm talking about when I mention it. I'm still wondering about possible side effects as it seems like body & joint pains were getting worse but ironically responded somewhat to antibiotic for respiratory infection!!!! I've seen a slight improvement in the asthma although every time I get a cold it seems to completely set me back. Sinuses are not helped at all so far. I've also gone up to the max dose - 375 mgs every 2 weeks.
>
> Thanks so much for your insights!
>
> > If your heart is enlarged concentrically or already eccentrically hypertrophied (?) it makes sense to lower your pulmonary resistence. Take care of pulmonary infections (pneumonia). Antibody treatments are still experimental. If there's only one aminoacid structure, glycolisation more thus inconsistency it will have an effect on cells next by.
> >
> > Good luck with Xolair.
> >
> > warm regards
> >
> > sdb
>
>Hi lonely!
The heart size is enlarged is unprecise. Did they mesure the ejection fraction (EF). Under <30% it is very bad. If you have difficulty breathing while walking and you have diffuse swelling around the ankles it could be a sign of a
insufficiency. What happen's when your pulmonary resistance is increased continuously? For a longer time your right ventricle will have to pump more until it is no more able to compensate and it will be first hypertrophied due to compensation and then dilated when it is insufficient. That's called cor pulmonale.If you have mitral valve calcification (what diameter (?)) that decreases the ejection fraction during the ventricles diastole into the left ventricle. That means the left atrial pressure increases and because of that it will increase the A. pulmonalis pressure (pap) too (backwards).
heartrate-Volume * pulmonary vascular resistance (pvr) + left atrial pressure (plvo) = mean pressure A. pulmonalis pressure (pap).
A chronic pulmonary hypertension leads to right ventricle insufficiency. But a single mitral valve problem (eg. calcification) or left heart insufficiency will cause pulmonary hypertension too. One thing is clear: If you have left atrial enlargement and calcification of the mitral valve this can cause atrial arrhythmias probably atrial thrombus et cetera. If the left atria is enlarged the lung capillary pressure will be elevated following a right heart stress again and lung oedemas (respiratory problems). Resembles to a vicious circle.
Speak with a good cardiologist but also with a lung specialist about this at best.
Probably first less invasive approach and if necessary there are some invasive approaches. If you have mitralstenosis 50% survive 10 years.
you never had rheumatic fever?
It makes sense to find out what is the reason for your respiratory problems. Theoretically it can be the chronic respiratory problems due to allergens but it could only be the mitral valve problem or both.
Thanks, very interesting information about Xolair.
Will listen to that later.Bye for now,
sdb
ps. i am here in probably a week again.
try to learn the anatomy to understand more.
it make sense to understand before you decide to treat something.http://www.clevelandclinic.org/heartcenter/pub/guide/heartworks/bloodflow.htm
poster:sdb
thread:744012
URL: http://www.dr-bob.org/babble/health/20070701/msgs/772579.html