Posted by Phoenix1 on January 14, 2008, at 8:47:20 [reposted on January 16, 2008, at 2:37:26 | original URL]
In reply to , posted by on December 31, 1969, at 18:00:00
> > Here's an interesting one. (BTW, I take Nardil and grapefruit juice seems to do nothing) But, I just got a prescription for Biaxin for a sinus infection (claithromycin). I take zopiclone (for Americans think eszopiclone). Clarithromycin is a potent inhibitor of CYP3a4 that metabolizes zopiclone. So I would exect an increased effect on the zopiclone? The pharmacist gave me a vacant look and said the computer didn't point out an interaction when I brought this up. She would rather that I didn't bring up any questions unless the answer is in the computer. So much for the helpful old-time pharmacist. Your thoughts? )on the clarithromycin-zopiclone interaction thing)
> >
> > Phoenix1
>
> I would indeed expect a modest to significant interaction between the two. Luckily, there is another metabolic pathway (2E1) for the zopiclone, but you're still going to see an increase in both plasma concentration and AUC (total exposure).
>
> Lar
>Thanks Larry,
You are obviously very knowledgeable! Where did you learn so much about metabolic pathways etc.? Are you from the biz somehow? I'm slowly learning these things, but as a layperson with only some uni. level organic chem and biology, it's a slow go...
Phoenix1
poster:Phoenix1
thread:806889
URL: http://www.dr-bob.org/babble/neuro/20080114/msgs/806908.html